DOI: http://dx.doi.org/10.18203/2349-3933.ijam20163726

A study of clinical profile of patients presenting with abnormalities detected by upper gastrointestinal endoscopy

Radha Priya Yalamanchi, Veeren Ganta, Pradeep Kumar Mohapatra, Biswajit Sahu, Kota Raghvendar, Gudipati Anusha, Bharadwaj Bachu, C. Raghavendra Reddy

Abstract


Background: Alcoholic liver disease (ALD) continues to be a cause of disability and death throughout the world. According to two recent studies from the United States, 50-67% of the adult population drinks alcohol. The objective of the study was to study the upper gastrointestinal endoscopic abnormalities of patients with alcoholic Liver Disease.

Methods: We conducted an observational, cross-sectional study to study the upper gastrointestinal endoscopic abnormalities in patients with alcoholic liver disease. A total of 97 patients, who satisfied the inclusion and exclusion criteria have been enrolled into our study.

Results: On upper gastrointestinal endoscopy, 94.73% cirrhotic patients were found to have esophageal varices (P<0.001), 23.68% cirrhotic patients were found to have esophagogastroduodenal PHG (P = 0.04) and 15.78 % cirrhotic patients were found to have GAVE. None of the patients with USG findings of fatty liver / acute hepatitis had the above endoscopic abnormalities.

Conclusions: Most significant clinical association’s esophageal varices and portal hypertensive gastropathy. Early detection and management of the above conditions may be helpful in lowering the disease burden and its morbidity.


Keywords


Acute hepatitis, Esophageal varices, Fatty liver

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References


Kim WR, Brown RS, Terrault Na. Burden of liver disease in the United States: Summary of a workshop. Hepatology. 2002;36:227-42.

Foster SE, Vaughan RD, Foster WH. Alcohol consumption and expenditures for underage drinking and adult excessive drinking. JAMA. 2003;289:989-95.

Rabinovitz M, Yoo YK, Schade RR. Prevalence of endoscopic findings in 510 consecutive individuals with cirrhosis evaluated prospectively. Dig Dis Sci. 1990;35:705-10.

Fassio E, Viudez P, Landeria G. Upper digestive hemorrhage in liver cirrhosis: clinical and endoscopic findings. Acta Gastroenterol Latinoam. 1992;22:181-6.

Orloff MJ, Isenberg JI, Wheeler HO. Alcoholic versus nonalcoholic cirrhosis in a randomized controlled trial of emergency therapy of bleeding varices. J Surg Res. 2012;174:98-105.

Mishra P, Desai N, Alexander J. Applicability of MELD as a short-term prognostic indicator in patients with chronic liver disease: an Indian experience. J Gastroenterol Hepatol. 2007;22(8):1232-5.

Roy K, Chawla LS, Sabharwal BD. Alcoholic liver disease in Punjab. Indian J Gastroenterol. 1985;4(3):161-2.

Hourigan KJ, Bowling FG. Alcoholic liver disease: a clinical series in an Australian private practice. J Gastroenterol Hepatol. 2001;16(10):1138-43.

Arico S, Galatola G, Tabone M. The measure of life-time alcohol consumption in patients with cirrhosis: reproducibility and clinical relevance. Liver. 1995;15(4):202-8.

Bosch J, Abraldes JG, Groszmann R. Current management of portal hypertension. J Hepatol. 2003;38(1):S54-68.

Suzuki A, Mendes F, Lindor K. Diagnostic model of esophageal varices in alcoholic liver disease. Eur J Gastroenterol Hepatol. 2005;(17):307-9.

Primignani M, Carpinelli L, Preatoni P. Natural history of portal hypertensive gastropathy in patients with liver cirrhosis. The New Italian Endoscopic club for the study and treatment of esophageal varices (NIEC). Gastroenterology. 2000;119:181-7.

Sarin SK, Shahi HM, Jain M. The natural history of portal hypertensive gastropathy: influence of variceal eradication. Am J Gastroenterol. 2000;95(10):2888-93.

Ward EM, Raimondo M, Rosser BG. Prevalence and natural history of gastric antral vascular ectasia in patients undergoing orthotopic liver transplantation. J Clin Gastroenterol. 2004;38(10):898-900.