Assessment of urinary interleukin-18 in the early post-burn period to predict acute kidney injury of various degrees of burn patients


  • Sharif Qamar Uddin Dhaka University Medical Center and Hospital, Dhaka, Bangladesh
  • M. Nazrul Islam Department of Nephrology, Dhaka Medical College Hospital Dhaka, Bangladesh
  • M. Nizamuddin Chowdhury Department of Nephrology, BRB Hospital Limited, Dhaka, Bangladesh
  • Nizam Uddin Ahmed Chowdhury Department of Nephrology, Sheikh Fazilatunnessa Mujib Memorial KPJ Specialized Hospital, Gazipur, Bangladesh
  • Mohammad Zahir Uddin Department of Nephrology, Cumilla Medical College Hospital, Cumilla, Bangladesh
  • Maksuda Begum Mony Department of Nephrology, Universal Medical College, Dhaka, Bangladesh



Burn patients, Study, Admission, Urinary, AKI, Urinary IL18, Early


Background: Early detection of acute kidney injury (AKI) in burn-injured patients can help modify the treatment to prevent progression of acute renal failure and reduce the need for renal replacement therapy. The aim of the study was to evaluate urinary interleukin-18 in the early post-burn period to predict the AKI for the various degrees of burn patients.

Methods: This prospective observational study was conducted in the department of nephrology, Dhaka medical college in collaboration with burn and plastic surgery unit of the same medical college hospital, from July 2017 to June 2018 for a period of one year. The 48 burn patients (Age>18 years) who attended in the burn unit of Dhaka medical college, Dhaka of both sexes were enrolled in this study. Data were analyzed by using SPSS 22.0. A value of p<0.05 was considered statistically significant for all tests.

Results: In this study, mean age of the burn patients was 32.41±10.59 years. Male female ratio was 3.36:1. Urinary IL-18 in diagnosis of AKI showed accuracy, sensitivity, specificity, positive predictive value (PPV) and negative predictive value (NPV) were 93.8%, 91.7%, 94.4%, 84.6% and 97.1% respectively. AUC for urinary IL-18 at admission was 0.968 (CI, 0.921-1.000) and AUC for serum creatinine at admission was 0.937 (CI, 0.871-1.000).

Conclusions: According to Kappa value, AUC and sensitivity and specificity urinary IL-18 is a good biomarker in predicting of early AKI in burn patients.

Author Biography

Sharif Qamar Uddin, Dhaka University Medical Center and Hospital, Dhaka, Bangladesh

Senior Medical Officer, Dhaka University Medical Center & Hospital, Dhaka, Bangladesh


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