Infrascapular granular cell tumor: an unusual entity

Sabina Khan, Sujata Jetley


Granular cell tumor (GCT) is an uncommon soft tissue tumor of schwannian origin frequent among women and blacks between the second and sixth decades of life. The common location of GCT is the oral cavity, but it can also occur at other sites. Cutaneous lesions constitute about 30% of cases and are characterized by a gradually developing nodular lesion. Due to their subtle clinical appearance and symptomatology, GCTs are often misdiagnosed. We report a case of subcutaneous GCT in the infrascapular region in a 40 year old female which mimicked granular cell dermatofibroma on histopathology. Although a rare entity, Granular cell tumor should be considered in the differential diagnosis of the subcutaneous soft tissue tumours and require histopathological examination along with immunohistochemistry to confirm the diagnosis and differentiate them from other benign and malignant tumors showing granular cell change.


Granular cell tumor, Histopathology, Subcutaneous

Full Text:



Tsuneyoshi M, Enjoji. Granular Cell tumor: a clinicopathologic study of 48 cases. Fukuoka Acta Medica. 1978;69:495-505.

Apisarnthanarax P. Granular cell tumor. An analysis of 16 cases and review of the literature. Am Acad Dermatol. 1981;5:171-82.

Becelli R, Perugini M, Gasparini G, Cassoni A, Fabiani F. Abrikosoffs tumor. J Craniofac Surg. 2001;12:78-81.

Lack EE, Worsham GM, Calihan MD, Crawford BE, Klappenback S, Rowden G. Granular cell tumor: a clinicopathological study of 110 patients. J Surg Oncol. 1980;13:301-16.

Fragulidis GP, Chondrogiannis KD, Lykoudis PM, Karakatsanis A, Georgiou CA, Vouza E, Melemeni A. Subcutaneous granular cell tumour of the lumbar region. J Cutan Aesthet Surg. 2011;4:132-4.

Smith JC, Kindblom JM, Fante R, Kindblom LG. Malignant granular cell tumor of soft tissue: diagnostic criteria and clinicopathologic correlation. Am J Surg Pathol. 1998;22:779-94.

Weiss SW, Goldblum JR. Granular cell tumor in soft tissue tumors. Enzinger FM, Weiss SW 5th Edition. Mosby, St Louis, USA. 2008:878-87.

Soyer HP, Metze D, Kerl H. Granular cell dermato fibroma. Am J Dermatopathol. 1997;19:168-73.

Bernal JF, Mira C. Dermatofibroma with granular cells. J Cutan Pathol. 1996;23:562-5.

Cheng SD, Usmani AS, Deyoung BR, Ly M, Pellegrini AE. Dermatofibroma-like granular cell tumor. J Cutan Pathol. 2001;28:49-52.