DOI: https://dx.doi.org/10.18203/2349-3933.ijam20220042
Published: 2022-01-25

Long-term effectiveness and safety of endoxifen in the treatment of bipolar mania: a case report

Vaibhav Dubey

Abstract


Bipolar disorder (BD) displays abnormalities in protein kinase C (PKC) signaling, and evidence suggests that inhibiting PKC may help treat mania. Endoxifen a potent inhibitor of the PKC signaling pathway, is effective in controlling acute bipolar mania, at doses of 8 mg OD, for a period of 3-weeks. Here we present the case of a patient with severe mania, increased alcohol consumption administered endoxifen 8 mg BID for a period of 3-months, to achieve a better response. High-dose, long-term treatment with endoxifen was efficacious in controlling manic symptoms, with no adverse effects. Additionally, the patient didn’t consume alcohol during the course of treatment. This case showed the long-term effectiveness and safety of high-dose endoxifen to control mania in a patient with BD.


Keywords


Endoxifen, Bipolar mania, Severe mania, Long-term use, Safety, Effectiveness

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