A study of gonadal dysfunction in women with thyroid disease


  • Manasa Saligrama Vasudevan Department of Medicine, Mysore Medical College and Research Institute, Mysore, Karnataka, India
  • Naveenkumar Hosalli Department of Medicine, Mysore Medical College and Research Institute, Mysore, Karnataka, India http://orcid.org/0000-0002-1379-4976




Hypothyroidism, TSH, Oligomenorrhea, Prolactin, Hyperthyroid, PCOD


Background: Thyroid diseases are among the commonest endocrine disorders. It effects growth, embryonic development, tissue differentiation, maturation, metabolism, increases chronotropic and inotropic action of heart. The aim was to study gonadal dysfunction in women with thyroid disease; to study levels of FSH, LH, prolactin, estrogen and testosterone in hypothyroid and hyperthyroid.

Methods: All participants fulfilling the inclusion criteria were interviewed as per proforma and medical details were recorded in proforma sheet and patients were subjected to necessary blood investigations.

Results: Among 80 study subjects, majority were in the age group 26-35 years (60.1%) and majority had overt hypothyroid disease (72.5%). Symptoms of hypothyroid subjects mainly were fatigue, weight gain, hair loss, oligomenorrhea. Hyperthyroid subjects had fatigue, palpitations, oligomenorrhea, polymenorrhea. Prolactin had positive correlation with TSH in hypothyroid subjects, their LH, FSH levels were normal and sex steroid levels were low. In contrary, majority of the hyperthyroid subjects had normal prolactin and FSH, high LH and high sex steroid levels.

Conclusions: The study demonstrated that thyroid disease in women causes menstrual abnormalities due to altered gonadotropin patterns which in turn alter ovarian hormone pattern. Hypothyroidism is associated with hyperprolactinemia leading to anovulation and abnormal menstrual cycle. Hyperthyroidism is associated with increased levels of LH, estrogen and testosterone with normal levels of PRL and FSH. Screening, identifying and correcting thyroid disease should be undertaken to prevent infertility as early as possible.

Author Biography

Naveenkumar Hosalli, Department of Medicine, Mysore Medical College and Research Institute, Mysore, Karnataka, India

Department of general medicine


Ellis H. The early days of thyroidectomy. J Perioper Pract. 2011;21(6):215-6.

Veeresh T, Moulalli D, Sarma VHS. A study on serum FSH, LH, and prolactin levels in women with thyroid disorders. Int J Scientif Res. 2015;5(3).

Krassas GE, Poppe K, Glinoer D. Thyroid function and human reproductive health. Endocr Rev. 2010;31(5):702-55.

Koutras DA. Disturbances of menstruation in thyroid disease. Ann N Y Acad Sci. 1997;816:280-4.

Kalra S, Unnikrishnan AG, Sahay R. Thyroidology and public health: the challenges ahead. Indian J Endocrinol Metab. 2011;15(2):73-5.

Azziz R. Diagnosis of polycystic ovarian syndrome: the rotterdam criteria are premature. J Clin Endocrinol Metabol. 2006;91(3):781-5.

Saran S, Gupta BS, Philip R, Singh KS, Bende A, Agroiya P, et al. Effect of hypothyroidism on female reproductive hormones. Indian J Endocrinol Metabol. 2016;20(1).

Lal RZ, Biyani S, Lodha R. Correlation of thyroid hormones with fsh, lh and prolactin in infertility in the reproductive age group women. IAIM. 2016;3(5):146-50.

Krassas GE. Thyroid disease, menstrual function and fertility. Fertil Steril. 2000;74(6):1063-70.

Jameson JL, Mandel SJ, Weetman AP. Thyroid gland and physiology and testing: Harrison principles of internal medicine. 20th ed. USA: McGraw Hill; 2018: 2701.

Salvatore D, Daves TF, Schlumberger MJ, Hay ID, Larsen PR. Thyroid physiology and diagnostic evaluation of patients with thyroid disorders. Williams endocrinology. 13th ed. Philadelphia: Elsevier; 2016: 336.

Kanwar G, Jain N, Shekawat M, Sharma N. Estimation of LH, FSH, prolactin and TSH levels in Polycystic Ovarian Syndrome and Correlation of LH and FSH. J Family Med Prim Care. 20198(1):256-60.






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