Study of clinical and etiological profile of new onset seizure in adults reporting to tertiary care centre, Mysore


  • Naveen Kumar Hosalli Department of Medicine, Mysore medical college and research institute, Mysore, Karnataka, India
  • Manasa Saligrama Vasudevan Department of Medicine, Mysore medical college and research institute, Mysore, Karnataka, India
  • Mahammad Iliyas Jalageri Department of Medicine, Mysore medical college and research institute, Mysore, Karnataka, India



Seizures, ILAE, Generalised seizures, Alcohol withdrawal



Background: Overall incidence of seizure is found to be 0.2-0.6 per 1000 population per year. A first seizure mandates individual counselling about the risk of recurrence, the pros and cons of drug treatment. Seizures are usually a manifestation of an underlying pathology which may be genetic, structural or metabolic. Objectives of current study were to study the clinical profile of new onset seizures in adults (greater than 19 years) attending to tertiary care Centre, Mysore and to determine the etiology of new onset seizures in adults reporting to tertiary care centre, Mysore.

Methods: All participants fulfilling the inclusion criteria were interviewed as per proforma. Participant’s demographic, social and medical details were recorded in proforma sheet and patients were subjected to neuroimaging studies, EEG and other necessary blood investigations. In all cases the seizure type is classified according to ILAE Classification 2017.

Results: Among 100 cases evaluated for new onset, Majority of the patients were 41 to 60 years. Generalised seizures (95%) were more common than focal seizures.

Among neurological etiological causes, vascular causes (34%) were most common. Most common Non-neurological cause for seizures was alcohol withdrawal (46.67%).

Conclusions: If proper analysis of etiology is made, seizures can be treated accordingly thus reducing the morbidity and mortality associated with it. Primary care physicians play a pivotal role in identifying patients with adult onset seizures and should encourage these patients to undergo neuroimaging so as to arrive at an appropriate etiological diagnosis.


Amudhan S, Gururaj G, Satishchandra P. Epilepsy in India I: Epidemiology and public health. Ann Indian Acad Neurol. 2015;18(3):263-77.

Daniel HL. Seizures and Epilepsy. In: Jameson JL, Fauci AS, Kasper DL, Hauser SL, Lango DL, Loscalzo J (eds). Harrison’s principles of internal medicine. 20th ed. New York:McGraw-Hill;2018.

Sheikh NA, Nasreena Shabnum2, Gulzar A. Bhat1, Atif Kawoosa1, Mudasir Mushtaq1, Mushtaq A. Wani. Etiological profile of adult onset seizures: a hospital based prospective study from Kashmir, India. Int J Adv Med. 2017;4(3):793-8.

Sander JW, Hart YM, Johnson AL, Shorvon SD. National General Practice Study of Epilepsy: newly diagnosed epileptic seizures in a general population. Lancet. 1990;336:1267-71.

Muralidhar V, Venugopal K. New onset seizures: Etiology and co-relation of clinical features with computerized tomography and electroencephalo graphy. J Sci Soc. 2015;42:82-7.

Chalasani S, Kumar MR. Clinical profile and etiological evaluation of new onset seizures after age 20 years. Int J Adv Med. 2017;4(2):901-8.

Joshi MA. Etiological evaluation of new onset seizures. Sch J App Med Sci. 2017;5(2E):620-5.

Maria G, Souza A. Epilepsy: over 50 years of age. Arq Neuropsiquiatr. 2012;70(10):780-5.

Forsgren L. Prospective incidence study and clinical characterization of seizures in newly referred adults. Epilepsia. 1990;31(3):292-301.

Jallon P, Smadja D, Cabre P, Le Mab G, Bazin M. EPIMART: Prospective incidence study of epileptic seizures in newly referred patients in a french carribean island (Martinique). Epilepsia. 1999;40(8): 1103-9.

Rajadhyaksha GC, Singh AC. New Onset Seizures in Adults. Int J Educ Res Health Sci. 2017;3(1):42-7.

Rao C, Rao SN, Sridevi A, Kumar NA, Srinivas M, Buchineni M. Clinical and radiological evaluation of new-onset epiletic seizures in a tertiary care hospital. J Evid Med Healthcare. 2015;2(39):6452-7.

Ashwin T. Evaluation of Seizures. Int J Adv Med. 2017;4(2):490-6.

King MA, Newton MR, Jackson GD. Epileptology of the first-seizure presentation: a clinical, electroen cephalographic, and magnetic resonance imaging study of 300 consecutive patients. Lancet. 1998;352: 1007-11.

Murthy JMK, Yangala R. Acute symptomatic seizures incidence and etiological spectrum: a hospital-based study from South India. Seizure. 1999;8:162-5.

Annegers JF, Hauser WA, Beghi E. The risk of unprovoked seizures after encephalitis and meningitis. Neurology. 1988;38:1407-10.

Rao BS, Vani MS, Varma GA. The study of etiological profile in new onset seizures in Indian scenario. Int J Adv Med. 2015;2(1):6-12.

Kanitkar SA, Gaikwad AN, Kalyan M, Aarwal R, Krunal K, Tamakuwala KK et al. Study of seizure disorder in elderly: Etiology, types, EEG and image findings. Transworld Med J. 2013;1:24 5.






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