Topical therapy of various dermatoses with ImpoyzTM (clobetasol propionate) cream 0.025%


  • Mahendra Haribhai Vaghasiya Department of Dermatology, Shri Hari Skin Care, Surat, Gujarat, India
  • Sanjay Kumar Dayani Department of Dermatology, Skin Care Clinic, Nagpur, Maharashtra, India
  • Ravi Munasing Rathod Department of Dermatology, Skin Care Center, Hubli, Karnataka, India
  • Arun Kumar Chatterjee Department of Dermatology, Skin Care Clinic, Patparganj, Delhi, India
  • Balachandra S. Ankad Department of Dermatology, S. Nijalingappa Medical College, Bagalkot, Karnataka, India
  • Saleem Abdulhasanbeg Jamadar Department of Dermatology, Jamadar's Skin Care Clinic, Gadag-Betageri, Karnataka, India
  • Umesh Omkarlal Agrawal Department of Dermatology, Priyal Skin Care Clinic, Dahod, Gujarat, India
  • Jayesh Sanaryia Amrutlal Department of Dermatology, Sparsh Skin and Cosmetic Clinic, Morbi, Gujarat, India
  • Mahendra Kumar Singhi Department of Dermatology, Singhi Clinic, Jodhpur, Rajasthan, India
  • Mashkoor Ahmed Wani Department of Dermatology, Shah Multispeciality Clinic, Thane, Mumbai, Maharashtra, India



Clobetasol propionate 0.025%, Plaque psoriasis, Psoriasis, Topical corticosteroids


The most widely prescribed drugs for the treatment of a variety of dermatoses are Topical corticosteroids (TC). These medications are approved for the treatment of inflammatory and pruritic manifestations of dermatologic disorders due to their powerful symptom-relieving impact. Clobetasol propionate (CP) is the most popular (TC) used to relieve itching, redness, and oedema caused by a variety of skin disorders. Anti-inflammatory, anti-pruritic, and vasoconstrictive characteristics are all present in it. CP works by binding to cytoplasmic glucocorticoid receptors and activating glucocorticoid receptor-mediated gene expression, resulting in the production of anti-inflammatory proteins while suppressing the production of inflammatory mediators. The formulation is free from known contact allergens, such as propylene glycol, short-chain alcohols, and sorbitol-based emulsifiers, and has demonstrated hypoallergenic effects. The efficacy, safety, and clinical experience of utilizing CP 0.025% cream for the treatment of various dermatologic disorders are discussed in this case series.



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