Biochemical abnormalities in patients presenting with acute organo-phosphorus poisoning in a tertiary care hospital, and the prognostic significance

Sneh Sonaiya, Rupal Dosi


Background: Organophosphate poisoning is a major cause of morbidity and mortality that poses public health problems in developing countries, including India. Clinical signs and symptoms of OP compound ingestion are often non-specific and clinical signs depend on the nature of the OP compound, the amount consumed the time lapse between exposure and admission to the hospital, and the severity

Methods: In this prospective cohort study, we reported the clinical presentation of 50 patients with OP poisoning, and studied the correlation of serum K+, Na+, creatinine, and BUN with the prognostic significance.

Result: Elevated serum creatinine along with hypokalemia was found to be strongly correlated with high mortality rates in patients with suicidal organophosphate poisoning. The correlation of clinical outcomes and low serum K+ was found to be statistically significant (p<0.001). Our study concludes that serum K+ (<3.6 mmol/l) and serum creatinine (>1.21 mg/dl) are poor prognostic indicators for patients presenting with suicidal OP poisoning

Conclusions: Our study concluded the association of hypokalemia and elevated serum creatinine levels with poor clinical outcomes in OP poisoning patients, and recommends regular monitoring of these prognostic indicators in effective management of these patients


Organophosphate, Hypokalemia, Poisoning

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