Association of microalbuminuria in non-diabetic and non-hypertensive patients with myocardial infarction


  • Abhijit Basu Department of Medicine, Geetanjali Medical College & Hospital, Udaipur, Rajasthan, India
  • Jaswant Singh Jhala Department of Medicine, Geetanjali Medical College & Hospital, Udaipur, Rajasthan, India



Microalbuminuria, Total cholesterol, Myocardial infarction


Background: This study was designed to evaluate the association of microalbuminuria in non-diabetic and non-hypertensive patients with myocardial infarction and to determine whether microalbuminuria is an independent marker of Myocardial Infarction in non-diabetic and non-hypertensive patients.

Methods: This study was conducted over 50 patients diagnosed as ST-segment elevation acute myocardial infarction on the basis of clinical history, examination, ECG changes, & biochemical markers. Cases were selected from a tertiary care hospital, Udaipur.

Results: In our study out of the 50 cases 66% (n=33) had microalbuminuria. The difference was statistically significant P <0.001. Microalbuminuria was found in a lower age group (48.76 ± 6.97) in cases as compared to controls (54.5 ± 4.12) (P <0.05). Among the 30 males in cases 25 (83.33%) had microalbuminuria. (P <0.05) microalbuminuria is seen more among smokers (P <0.001). In cases, 26 had a BMI >25 of these 80.76% (n=21) had microalbuminuria. Microalbuminuria is associated with high cholesterol in IHD.  

Conclusions: The microalbuminuria is significantly associated with in non-diabetic non-hypertensive myocardial infarction. Microalbuminuria is seen at a younger age group in MI. Microalbuminuria is associated with male sex significantly. Microalbuminuria is strongly associated with smoking, high body mass index and high total cholesterol. Microalbuminuria is seen independent of smoking status, BMI, total cholesterol in patients of myocardial infarction. 


Enas EA, Senthilkumar A. Coronary artery disease in Asian Indians: an update and review. Internet J Cardiol. 2002;1(2):5.

Fernandez A, Mondkar J, Mathai S. Urban slum-specific issues in neonatal survival. Indian Paediatr. 2003;40:1161-6.

Madhiwala N. Healthcare in urban slums in India. Natl Med J India. 2007;20:113-4.

Agarwal P, Singh MM, Garg S. Maternal health-care utilization among women in an urban slum in Delhi. Indian J Community Med. 2007;32:203-5.

Hatekar N, Rode S. Truth about hunger and disease in Mumbai; Malnourishment among slum children. Econom Political Wkly. 2003;25:4604-10.

Montalescot G, Collet JP. Preserving cardiac function in the hypertensive patient: Why renal parameters hold the key. Eur Heart J. 2005;26:2616-22.

Naidoo DP. The link between microalbuminuria, endothelial dysfunction and cardiovascular disease in diabetes. Cardiovasc J South Afr. 2002;13:194-9.

Elliott M. Antman, Joseph Loscalzo. Chapter 245. In: Elliott M. Antman, Joseph Loscalzo, eds. Harrison’s Principles of Internal Medicine. 18th ed. New York: McGraw-Hill Professional; 2011: 2021.

Viberti GC, Mackintosh D, Bilous RW, Keen H. Proteinuria in diabetes mellitus, role of spontaneous and experiemental variation. Kidney. 1982;21:714-20.

Poulsen PE. Microalbuminuria-techniques of measurement. In: Mogensen CE, eds. Microalbuminuria A. Marker for Organ Damage. 2nd ed. London: Science Press Ltd.; 1993: 10.

Taskiran M, Feldt-Rasmussen B, Jensen GB, Jensen JS. Scand Urinary albumin excretion in hospitalized patients with acute myocardial infarction. Prevalence of microalbuminuria and correlation to left ventricle wall thickness. Cardiovasc J. 1998;32(3):163-6.

Agarwal B, Berger A, Wolf K. Luft FC. Microalbuminuria screening by reagent strip predicts cardiovascular risk in hypertension. J Hypertens. 1996 Feb;14(2):223-8.

Jensen JS, Feldt-Rasmussen B, Borch Johnson K, Clausen P, Appleyard M, Jensen G. Microalbuminuria and its relation to cardiovascular disease and risk factors: a population based study of 1254 hypertensive individuals. J Hum Hypertens. 1997 Nov;11(11):727-32.

Mimarm A. Microalbuminuria in essential hypertension. Clin Exp Hypertens. 1997 Jul-Aug;19(5-6):753-67.

Cirillo M, Seningalliesi L, Laurenzi M, Alfieri R, Stamler J. Stamler R, et al. The Gubbio population study. microalbuminuria in non-diabetic adults; relation of blood pressure, body mass index, plasma cholesterol levels, and smoking. Arch Intern Med. 1998 Sep;158(17):1933-9.

Jensen JS, Borch-Johnsen K, Jensen G, Feldt-Rasmussen B. Atherosclerotic risk factors are increased in clinically healthy subjects with microalbuminuria. Atherosclerosis. 1995 Jan;112(2):245-52.

Hillege HL, Janssen WM, Bak AA, Diercks FG, Grobee DE, Crijns JH, et al. Microalbuminuria is common also in a non-diabetic, non-hypertensive population, and an independent indicator of cardiovascular risk factors and cardiovascular morbidity. J Intern Med. 2001 Jun;249(6):519-26.






Original Research Articles