Comparative study of prevalence of hypothyroidism in cirrhotic patients and normal individuals
Keywords:Liver disease, Alcoholism, Serum albumin, Hypothyroidism
Background: Alcoholic cirrhosis has worse prognosis than primary billiary cirrhosis and cirrhosis due to hepatitis. The risk of death due to all cause is increased 12-fold with cirrhosis. Alcoholic liver cirrhosis develops between 10-20% of individuals who drink heavily for a decade or more. Chronic hepatitis B is probably the most common cause of cirrhosis worldwide. The aim and objective of this study was to compare the prevalence of hypothyroidism between cirrhotic patients and normal healthy individuals.
Methods: The present study constitutes of 50 patients with cirrhosis of liver who met our inclusion criteria. They were selected from the patients admitted in medical wards and gastroenterology ward of RNT medical college, Udaipur.
Results: Majority of patients were of serum albumin level class III about 67%. Increased TSH level as compare to level of serum albumin in cirrhotic patients. When serum albumin level decreases then percent of TSH level increases. Majority of patients were from serum bilirubin class III (71%). Majority were from serum bilirubin class III about 70%.
Conclusions: All cirrhotic patients should undergo for evaluation of endocrinological evaluation as these patients are associated with development of hypothyroidism. After diagnosis the treatment of endocrinological disorder especially hypothyroidism may increase survival.
Barue A. Treatment of alcoholic liver disease. Ann Hepatol. 2008;7(1):5-15.
Rambaldi A. Systemic review: Gluco-corticosteroid for alcoholic hepatitis-a cochrane hepato-biliary group review with meta analysis and trial sequential analysis of randomized clinical trials. Aliment Pharmacol Ther. 2008;27(12):1167-78.
Alcohol induced liver disease, 2021. Available at: http://www.liverfoundation.org/education/infoalcohol. Accessed on 20 November 2021.
Argo CK. Statins in liver disease: a Molehills, an Iceberg, or neither?. Hepatology. 2008;48:662-9.
Dusheiko G. Current treatment of hepatitis B. Gut. 2008;57(1):105-24.
Bell BP. The epidemiology of newly diagnosed chronic liver disease in gastroenterology practices in the United States: result from population based Surveillance. Am J Gastroenterol. 2008;103(11): 2727-36.
Beltran S. Subclinical hypothyroidism in chronic illness patients is not an autoimmune disease. Horm RTS. 2006;66(1):21-6.
Grün R, Kaffarnik H. Thyroid hormones in women with liver cirrhosis. Klin Wochenschr. 1985;63(16): 752-61.
Koenig RJ. Modeling the non thyroidal illness syndrome curropin endocrinal Diabetes Obes. 2008; 15(5):466-9.
Sterling K, Brenner MA. Free thyroxine in human serum: simplified measurement with the aid of magnesium precipitation. J Clin Invest. 1966;45:153-63.
Borzoi M, Caldara R, Borzio F, Piepal V, Rampin P. A Study of Thyroid Dysfunction in Cirrhosis of Liver and Correlation with Severity of Liver Disease. Indian J Endocrinol Metab. 2018;22(5):645-50.
Bruix J, Ishii K, Furudera S, Tanaka S, Kumashiro R, Sata M, et al. Chronic hepatitis C in alcoholic patients: studies with various HCV assay procedures. Alcohol Alcohol Suppl. 1993;1:71-6.
Schlienger JL, Jacques C, Sapin R, Stephan F. Thyroid function in patients with alcoholic cirrhosis. Ann Endocrinol. 1980;41(2):81-94.
Tsai MM, Liao CH, Yeh CT, Huang YH, Wu SM, Chi HC, et al. Dickkopf 4 positively regulated by the thyroid hormone receptor suppresses cell invasion in human hepatoma cells. Hepatology. 2012;55:910-20.
Yalow RS, Berson SA. Immunoassay of endogenous plasma insulin in man. J Clin Invest. 1960;39(7): 1157-75.