An interesting case of anemia with jaundice
Keywords:Hemoglobin E disease, Hemoglobinopathies, HbE Thalassemia
Hemoglobinopathies are haematalogical disorders that afflict millions of individuals worldwide. HbE is a hemoglobin variation caused by a mutation in the β globin gene that results in the substitution of glutamic acid for lysine at position 26 of the β globin gene. Hemoglobin (Hb) synthesis abnormalities are among the most prevalent inherited disorders. They can be quantitative (thalassemia syndrome) or qualitative (variant HbS). Hemoglobin E (HbE) is the second most common hemoglobin variation after hemoglobin S (HbS).
Jain D, Gupta SK, Singh T. Hemoglobin E disease with concomitant tuberculosis. Indian Journal of Pathology and Microbiology. 2008;51:570.
Vichinsky E. Hemoglobin E Syndromes. American Society of Hematology. 2007;(1):79-83.
Patne SCU, Shukla J. Hemoglobin E disorders in Eastern Uttar Pradesh. Indian Journal of Pathology and Microbiology. 2000;52(1):110-2.
Mias DD, Gulberson RD, Keren DF. The Range of Hemoglobin A2 in Hemoglobin E Heterozygotes as Determined by Capillary Electrophoresis. American Journal of Clinical Pathology. 2009;132:34-8.