A study of transfusion related adverse events at a tertiary care centre in North India: an initiative towards hemovigilance
Keywords:Hemovigilance, Transfusion reaction, Adverse events
Background: The goal of hemovigilance is to improve the transfusion safety. The present study was undertaken to detect and analyze the transfusion related adverse events as a pilot effort towards hemovigilance from the institution.
Methods: The present retrospective study was conducted in the Department of Transfusion Medicine, Government Medical College, Jammu from Jan 2014- Dec 2014. All the adverse events related to transfusion of blood and blood products reported to the department were recorded and analyzed as per Departmental Standard operating procedures.
Results: During 1 year study period 33,852 blood and blood components were issued to various clinical departments. Ninety four reactions were reported, the type of reaction observed were allergic reactions in 41.5%, followed by febrile non hemolytic transfusion reaction(FNHTR) in 35.5%, Acute hemolytic reactions in 11.7%, delayed hemolytic transfusion reactions(DHTR) in 4.2%, transfusion associated cardiac overload (TACO) in 4.2% and Bacterial sepsis in 2.1%.
Conclusion: The frequency of transfusion in our patients was found to be 0.27%. Factors such as rational use of blood components, improving storage conditions, bedside monitoring of transfusion and documentation of adverse events will help in improving transfusion safety.
Faber JC. Worldwide overview of existing hemovigilance system. Transf Aphere Sci. 2004;31:99-110.
Stainsby D, Faber JC, Jorjensen J. Rossi’s Principle of Transfusion Medicine. 4th edition, wiley Blackwell. Overview of hemovigilance; 683-697.
Bisht A, Singh S, Marwaha N. Hemovigilance program – India. Asian J trans Sci. 2013;7(1):73-4.
Mazzai CA, Popovsky MA, Kopko PM. Technical Manual. 16th edition. Maryland: American Asssociation of Blood Banks; 2008. Non infectious complications of blood transfusion.; 715-751.
Battacharya P, Marwaha N, Dhawan HK, Roy P, Sharma RR. Transfusion related adverse events at a tertiary care centre in North India. An institutional hemovigilance effort. Asian J Trans Sci. 2011;5(2):164-170.
Kumar P, Thapliyal R, Coshic P, Chatterjee K. Retrospective evaluation of adverse transfusion reaction following blood product transfusion from a tertiary care hospital: A preliminary step towards hemovigilance. Asian J Trans Sci. 2013;7(2):109-15.
Domen RE, Hoeltge GA. Allergic transfusion reactions: an evaluation of 273 consecutive reactions. Arch Pathol Lab Med. 2003;127(3):316-20.
Moore SB. Anaphylactic transfusion reactions- A concise review. Ir Med J. 1985;78:54-6.
Ulhman EJ, Isgris E, Wallherfenmanfechtel M, Goodnough LT. Prestorage universal WBC reduction of RBCs units does not affect the incidence of transfusion reactions. Transfusion 2001;41:997-1000.
Baele PL, Bruyere D, Deneys M. Bedside Transfusion Errors. Vox Sanguinis. 1994;66:117-21.
Goodnough LT and Lawrence T. Risks of transfusion reaction. Critical care medicine. 2003;31:678-86.
Moore SB, Taswell HF, Pineda AA. Delayed hemolytic transfusion reactions: evidence of need for an improved pretransfusion compatibility test. Am J Clin Path. 1980;74:94-7.
Lichtiger B, Thorton T, Hemolytic transfusion reaction in oncology patients: Experience in a large cancer centre. J Clin Oncol. 1984;2:438-42.
Robillard P, Karl Itaj N. Incidence of adverse transfusion reactions in Quebec Hemovigilance System. Vox Sang. 2002;83:120.
Stack G, Pomper GJ. Rossi’s Principles of Transfusion Medicine, 3rd edi. Philedelphia, PA: Lippincott Williams & Wilkins; 2002, Febrile, allergic and non immune transfusion reactions; 831.
Kathryn E, Webert, Blajchman MA. Tranafusion- related acute lung injury. Transfus Med Rev. 2003;17:252-62.
Sharma RR, Bhattacharya P, Thakral B, Saluja K, Marwaha N. Transfusion- related acute lung injury. Ind J Pathol Microbio.l 2009;52:561-3.
Kuehner MJ, Roth VR, Haley NR. Transfusion transmitted bacterial infection in the United States, 1998 through 2000. Transfusion. 2001;41:1493-9.