Stevens-Johnson syndrome induced by carbamazepine and amitriptyline in diabetic patient: a case report


  • Agus Dody Pranata Suadi Putra Department of Internal Medicine, Wangaya Regional Hospital, Denpasar, Bali, Indonesia
  • Ketut Suryana Department of Internal Medicine, Wangaya Regional Hospital, Denpasar, Bali, Indonesia
  • Dewi Catur Wulandari Department of Internal Medicine, Wangaya Regional Hospital, Denpasar, Bali, Indonesia
  • Ida Ayu Uttari Priyadarshini Department of Internal Medicine, Wangaya Regional Hospital, Denpasar, Bali, Indonesia



Steven-Johnson syndrome, Diabetes mellitus, Immune reactions


Stevens-Johnson syndrome (SJS) is systemic immune reactions (type IV hypersensitivity) that are usually present by blistering and erosions of skin and mucous membranes with involvement of multiple organ systems. The incidence of SJS is rare, with the common comorbidities are diabetes mellitus, epilepsy, hypertension, and stroke. This condition is associated with systemic proinflammatory state. Diabetes mellitus is a metabolic disorder that is characterized by abnormally elevated levels of blood glucose due to glucose intolerance, hyperglycemia, and impaired insulin secretion. Nowadays, pathogenesis of diabetes is considered to be dysregulation of immune factors that are recognized as important etiological components in the development of insulin resistance. We report a case of a 30-years-old man with fever and sore throat, who had type 2 diabetes mellitus (T2DM) and used carbamazepine and amitriptyline for diabetic neuropathy, then followed by redness and blistering on his lips, palates, face, and trunk which subsequently diagnosed with SJS.


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