Analysis of the relation between elevated neutrophil lymphocyte ratio, and erythrocyte sedimentation rate in Helicobacter pylori positive chronic gastritis patients
Keywords:H. pylori, Chronic gastritis, NLR, ESR
Background: Aim of the study was to analyse the relation between elevated neutrophil lymphocyte ratio (NLR), and erythrocyte sedimentation rate (ESR) in Helicobacter pylori (H. pylori) positive chronic gastritis patients, as compared to the control group containing H. pylori negative chronic gastritis patients.
Methods: Chronic gastritis patients were segregated in equal numbers based on H. pylori status. NLR was calculated, and ESR noted from the observations, comparison was done between the control and the study groups.
Results: A total of 100 patients were included in the study. The 50 each from the control and study group. An observation of elevation in NLR and ESR in H. pylori positive chronic gastritis patients, as compared to the control group was seen. With an average NLR of 2.43 and 1.43, in the control and study group, respectively.
Conclusions: Raise in NLR in H. pylori positive chronic gastritis patients with an associated raise in ESR suggests, the severity of the infection and the need for eradication and prevent complications.
Watari J, Chen N, Amenta PS, Fukui H, Oshima T, Tomita T et al. Helicobacter pylori associated chronic gastritis, clinical syndromes, precancerous lesions, and pathogenesis of gastric cancer development. World J Gastroenterol. 2014;20(18):5461-73.
Genta RM, Hamner HW. The significance of lymphoid follicles in the interpretation of gastric biopsy specimens. Arch Pathol Lab Med. 1994;118:740-3.
Väänänen H, Vauhkonen M, Helske T, Kääriäinen I, Rasmussen M, Tunturi-Hihnala H et al. Non-endoscopic diagnosis of atrophic gastritis with a blood test. Correlation between gastric histology and serum levels of gastrin-17 and pepsinogen I: a multicentre study. Eur J Gastroenterol Hepatol. 2003;15:885-91.
Bionda M, Kapoglou I, Wiest R. H. pylori-associated gastritis: diagnostic, treatment and surveillance. Ther Umsch. 2020;77(4):127-31.
Axon AT. Review article: is Helicobacter pylori transmitted by the gastro-oral route? Aliment Pharmacol Ther. 1995;9(6):585-8.
Calvet X, Ramírez Lázaro MJ, Lehours P, Mégraud F. Diagnosis and epidemiology of Helicobacter pylori infection. Helicobacter. 2013;18(1):5-11.
Atayan Y, Hacısalihoglu P. The correlation between tissue Helicobacter pylori severity and the increase in serum neutrophil/ lymphocyte ratio in patients with active chronic gastritis. Biomed Res Ind. 2017;28:4874-7.
Agah S, Khedmat H, Ghamar-Chehred ME, Hadi R, Aghaei A. Female gender and Helicobacter pylori infection, the most important predisposition factors in a cohort of gastric cancer: A longitudinal study. Caspian J Intern Med. 2016;7(2):136-41.
Bodger K, Wyatt JI, Heatley RV. Gastric mucosal secretion of interleukin-10: relations to histopathology, Helicobacter pylori status, and tumour necrosis factor-alpha secretion. Gut. 1997;40:739-44.
Mărginean CO, Cotoi OS, Pitea AM. Assessment of the relationship between Helicobacter pylori infection, endoscopic appearance and histological changes of the gastric mucosa in children with gastritis (a single center experience). Rom J Morphol Embryol. 2013;54:709-15.
Morgner A, Bayerdörffer E, Neubauer A, Stolte M. Malignant tumors of the stomach. Gastric mucosa-associated lymphoid tissue lymphoma and Helicobacter pylori. Gastroenterol Clin North Am. 2000;29(3):593-607.
Nalbant A, Aydin A. Association of Helicobacter pylori infection with vitamin D, hemogram parameters, and blood group. Turk J Acad Gastroenterol. 2017;16:1-5.