An interesting case of dermatomyositis with classical presentation
DOI:
https://doi.org/10.18203/2349-3933.ijam20222668Keywords:
Dermatomyositis, Classical, Tissue disorderAbstract
Dermatomyositis, a connective tissue disorder, is an idiopathic inflammatory myopathy characterised by skin manifestation. The diagnosis of dermatomyositis is based on rashes on the skin, progressive muscle weakness, elevated serum muscle enzymes, abnormal electromyogram, and abnormal findings on muscle biopsy. Hereby presenting this rare case of a 57-year-old female with dermatomyositis with all the typical clinical findings with interstitial lung disease.References
Suber TL, Cascicola-Rosen L, Rosen A. Mechanisms of disease: Autoantigens as clues to the pathogenesis of myositis. Nat Clin Pract Rheumatol. 2008;4:201-9.
Kalyan M, Kanitkar S, Gaikwad A, Kumar H. Dermatomyositis: a case report. J Mahatma Gandhi Inst Med Sci. 2016;21(1):53-5.
Marvi U, Chung L, Fiorentino DF. Clinical presentation and evaluation of dermatomyositis. Indian J Dermatol. 2012;57(5):375-81.
Bohan A, Peter JB.Polymyositis and dermatomyositis (second of two parts). N Engl J Med. 1975;292:403-7.
Pokhrel S, Pardhe BD, Giri N, Pokhrel R, Paudel D. Classical Dermatomyositis: A Case Report. Clin Cosmet Investig Dermatol. 2020;13:123-6.
Ghirardello A, Zampieri S, Iaccarino L. Anti-Mi-2 antibodies. Autoimmunity. 2005;38(1):79-83.
Mammen AL, Casciola-Rosen LA, Hall JC, Christopher-Stine L, Corse AM, Rosen A. Expression of the dermatomyositis autoantigen Mi-2 in regenerating muscle. Arthritis Rheum. 2009;60(12):3784-793.
Kashiwagi M, Morgan BA, Georgopoulos K. The chromatin remodeler Mi-2beta is required for establishment of the basal epidermis and normal differentiation of its progeny. Development. 2007;134(8):1571-82.
Fujimoto M. Dermatomyositis: myositis‐specific autoantibodies and skin manifestations. Clin Exp Neuroimmunol. 2012;3.
Okada S, Weatherhead E, Targoff IN, Wesley R, Miller FW. Global surface ultraviolet radiation intensity may modulate the clinical and immunologic expression of autoimmune muscle disease. Arthritis Rheum. 2003;48(8):2285-93.
