Hoffman’s syndrome-a rare neurological presentation of hypothyroid myopathy
Keywords:Hoffman’s syndrome, Hypothyroidism, Pseudo hypertrophy
Hoffman's syndrome is a rare form of hypothyroid myopathy, which causes proximal muscle weakness and pseudohypertrophy of muscles. It is a complication of untreated or uncontrolled Hypothyroidism.The neurological manifestations of hypothyroidism usually occur late in the course of disease. It is quite rare to present with neurological manifestations in the earlier stage of disease. Very few cases of Hoffman’s syndrome were reported from India. Here we report a case of 27-year-old male who presented to the medicine OPD with initial symptoms of proximal muscle weakness, fatigue and calf muscle hypertrophy. On further evaluation patient was found to have hypothyroid myopathy in the form of Hoffman’s syndrome.
Mangaraj S, Sethy G. Hoffman's syndrome-A rare facet of hypothyroid myopathy. J Neurosci Rural Pract. 2014;5(4):447-8.
Achappa B, Madi D. Hoffmann's Syndrome- A Rare Form of Hypothyroid Myopathy. J Clin Diagn Res. 2017;11(5):OL01-2.
Dudekula A, Fernandes M, Mahale A, Sharma H. Hoffmann Syndrome: An Unusual Cause of Proximal Muscle Hypertrophy. Res J Radiol. 2017;4:1-4.
Ranaweerage R, Perera S, Gunapala A. Hoffmann syndrome; a rare form of hypothyroid myopathy. Sri Lanka J Med. 2021;30(1):104-8.
Sidibe EH, Diop AN, Thiam A, Diagne PM, Sarr A, Toure M et al. Hoffmann's syndrome in hypothyroid myopathy. Report of a case in an African. Joint Bone Spine. 2001;68:84-5.
Melmed S, Polonsky KS, Reed Larsen P, Kronenberg HM. Williams Textbook of Endocrinology. 12th ed. Philadelphia: W.B. Saunders Company. The thyroid gland. 2011;410.
Udayakumar N, Rameshkumar AC, Srinivasan AV. Hoffmann syndrome: Presentation in hypothyroidism. J Postgrad Med. 2005;51:332-3.
Vasconcellos LF, Peixoto MC, De Oliveira TN, Penque G, Leite AC. Hoffman's syndrome: Pseudohypertrophic myopathy as initial manifestation of hypothyroidism. Case report. Arq Neuropsiquiatr. 2003;61:851-4.
Deepak S, Harikrishnan, Jayakumar B. Hypothyroidism presenting as Hoffman's syndrome. J Indian Med Assoc. 2004;102:41-2.
Horak HA, Pourmand R. Endocrine myopathies. Neurol Clin. 2000;18:203-13.
Scott KR, Simmons Z, Boyer PJ. Hypothyroid myopathy with a strikingly elevated serum creatine kinase level. Muscle Nerve. 2002;26:141-4.
Barahona MJ, Mauri A, Sucunza N, Paredes R, Wägner AM. Hypothyroidism as a cause of rhabdomyolysis. Endocr J. 2002;49:621-3.
Udayakumar N, Rameshkumar AC, Srinivasan AV. Hoffmann syndrome: Presentation in hypothyroidism. J Postgrad Med. 2005;51:332-33.
Praveen KA, Aslam S, Dutta TK. Hoffmann’s syndrome: A rare neurological presentation of hypothyroidism. Int J Nutr Pharmacol Neurol Dis. 2011;1:201-03.
Nalini A, Govindaraju C, Kalra P, Kadukar P. Hoffmann’s syndrome with unusually long duration: report on clinical, laboratory and muscle imaging findings in two cases. Ann Indian Acad Neurol. 2014;17:217-21.
Senanayake HM, Dedigama AD, De Alwis RP, Thirumavalavan K. Hoffmann syndrome: a case report. Int Arch Med. 2014;7:2.