Phenytoin induced Lyell’s syndrome: a case report
DOI:
https://doi.org/10.18203/2349-3933.ijam20223403Keywords:
Lyell's syndrome, SJS, TENAbstract
Lyell’s syndrome commonly known as Stevens–Johnson syndrome (SJS) and toxic epidermal necrolysis (TEN) is a type of severe allergic reactions affecting the skin and mucous membranes. If surface area of the body (BSA) involvement is less than 10% which is called as SJS and TEN is defined as epidermal detachment >30% of the total body surface area while both SJS and TEN can have involvement of mucosa. BSA with 10–30%, there is overlapping of SJS and TEN. We report a rare, life-threatening case of Lyell’s syndrome who presented lesions involving 30% of BSA after the oral intake of phenytoin and she was successfully treated with high-dose steroids and supportive care.
References
Jayalekshmi K, Palanisamy K, Ramanathan S, Akela S. A study on the Adverse Drug Reactions induced by Anti-Epileptic Drugs in the epileptic patients. J App Pharm Sci. 2016:7(5):119-23.
Menon VB, Kurian J, Undela K, Ramesh M, Gowdappa HM. Phenytoin Toxicity: A case report. J Young Pharm. 2015;7(3):272-5.
Indu TH, Basutkar RS. Hypersensitivity reaction associated with phenytoin. J Basic Clin Pharma. 2015;6:119-21.
Singh S¸ Salman MT, Karauli R, Tewari S, Rai RK. Phenytoin induced Stevens-Johnson syndrome in a 38-yearmale patient: A case report. Int Arch BioMed Clin Res. 2015;1(1):28-30.
Al-Quteimat. Phenytoin-induced toxic epidermal necrolysis: Review and recommendations. J Pharmacol Pharmacother. 2016:7:127-32.
Chave TA, Mortimer NJ, Sladden MJ, Hall AP, Hutchinson PE. Toxic epidermal necrolysis: Current evidence, practical management and future directions. Br J Dermatol. 2005;153:241-53.
Lissia M, Mulas P, Bulla A, Rubino C. Toxic epidermal necrolysis (Lyell's disease). Burns. 2010;36:152-63.
Pillai LV, Ambike DP, Hussainy SMK, Vishwasrao S, Pataskar S, Gaikwad MM. Hypersensitivity and dose related side effects of phenytoin mimicking critical illness. Indian J Crit Care Med. 2005;9(1):22-7.
