Hepato-pancreatic fat-fetuin A based axis in context of diabetes and its reversal

Jayakrishnan B.

doi:10.18203/2349-3933.ijam20223413

Authors

Jayakrishnan B. Department of Medicine, Educare Institute of Dental Science Malappuram, Kerala and Safe Care Clinics, Tirur, Kerala, India

DOI:

https://doi.org/10.18203/2349-3933.ijam20223413

Keywords:

T2DM, Pancreatic fat, Obesity, Diabetes reversal

Abstract

Recent research has focused on reversing type 2 diabetes mellitus (T2DM) via lifestyle-related approaches, including low-calorie diets. Metabolic parameters such as fat accumulation in the liver and pancreas have garnered much attention in this context. Pancreatic fat has been linked with adverse metabolic consequences including T2DM and metabolic syndrome. Obesity is the primary factor leading to ectopic fat in organs such as the liver and pancreas. This review examines the potential role of pancreatic fat in the pathogenesis of T2DM and whether it can be a potential target in reversing this chronic condition.

Metrics

Metrics Loading ...

References

Tariq H, Nayudu S, Akella S, Glandt M, Chilimuri S. Non-alcoholic fatty pancreatic disease: a review of literature. Gastroenterol Res. 2016;9:87-91.

Dite P, Blaho M, Bojkova M, Jabandziev P, Kunovsky L. Nonalcoholic Fatty Pancreas Disease: Clinical Consequences. Dig Dis. 2020;38(2):143-9.

Rebours V, Gaujoux S, d’Assignies G, Sauvanet A, Ruszniewski P, Lévy P, et al. Obesity and fatty pancreatic infiltration are risk factors for Pancreatic Precancerous Lesions (PanIN). Clin Cancer Res. 2015;21:3522-8.

Malli A, Li F, Conwell DL, Cruz-Monserrate Z, Hussan H, Krishna SG. The burden of systemic adiposity on pancreatic disease: acute pancreatitis, non-alcoholic fatty pancreas disease, and pancreatic cancer. JOP. 2017;18:365-8.

Fukase A, Fukui T, Sasamori H, Hiromura M, Terasaki M, Mori Y, et al. Pancreatic fat accumulation evaluated by multidetector computed tomography in patients with type 2 diabetes. J Diabetes Investig. 2020;11(5):1188-96.

Silva LLSE, Fernandes MSS, Lima EA, Stefano JT, Oliveira CP, Jukemura J. Fatty Pancreas: Disease or Finding? Clinics (Sao Paulo). 2021;76:e2439.

Smits MM, van Geenen EJ. The clinical significance of pancreatic steatosis. Nat Rev Gastroenterol Hepatol. 2011;8:169-77.

Zhang CL, Wang JJ, Li JN, Yang Y. Nonalcoholic fatty pancreas disease: An emerging clinical challenge. World J Clin Cases. 2021;9(23):6624-38.

Macauley M, Percival K, Thelwall PE, Hollingsworth KG, Taylor R. Altered Volume, Morphology and Composition of the Pancreas in Type 2 Diabetes. PLoS One. 2015;10(5):e0126825.

Singh RG, Yoon HD, Wu LM, Lu J, Plank LD, Petrov MS. Ectopic fat accumulation in the pancreas and its clinical relevance: A systematic review, meta-analysis, and meta-regression. Metabolism. 2017;69:1-13.

Taylor R. Type 2 diabetes and remission: practical management guided by pathophysiology. J Intern Med. 2021;289(6):754-70.

Bourebaba L, Marycz K. Pathophysiological Implication of Fetuin-A Glycoprotein in the Development of Metabolic Disorders: A Concise Review. J Clin Med. 2019;8(12):2033.