Early imaging to detect bone metastatic disease of a 54-year-old woman with history of breast cancer: a case report

Authors

  • I. Made Bayu Surya Dana Department of Medicine, Dharma Yadnya General Hospital, Denpasar, Bali, Indonesia
  • I. Nyoman Teri Atmaja Department of Radiology, Dharma Yadnya General Hospital, Denpasar, Bali, Indonesia

DOI:

https://doi.org/10.18203/2349-3933.ijam20230063

Keywords:

Cancer, X-rays, Acetabulum, Metastatic

Abstract

The World Health Organization (WHO) has predicted a global amount of 19 million cancer case in 2025. After the lungs and liver, bone is the third most common site of tumour spread. The bone is a dynamic tissue that plays a critical role not only in structural support and movement, a reservoir for minerals and energy, but also houses of the bone marrow, which is the main site of postnatal hematopoiesis. A 54-year-old Indonesian woman presented to orthopaedist with complaints of sudden left hip pain and progressive difficulty in walking for three weeks. She reported severe pain that is exacerbated by any physical activity and movement. She has a medical history of breast cancer (pathologically confirmed in Sanglah General Hospital) which had undergone radiotherapy and chemotherapy a year ago. Outpatient left hip X-rays revealed lytic lesions at left acetabulum to left ilium, suggestive of metastatic disease. The established imaging techniques projectional radiography, skeletal scintigraphy, computed tomography (CT), magnetic resonance imaging (MRI), and positron emission tomography (PET) have undergone further development, with a resulting improvement in their diagnostic yield.

References

Sliepen SHJ. Bone Cancer Pain, Mechanism and Treatment. Intechopen. 2021.

Cheyne MN, Nichols D, Kumar A. The Diagnosis and Management of Metastatic Bone Disease in General Practice. InnovAiT. 2021;14(7):430-5.

Fornetti J, Welm AL, Stewart SA. Understanding the Bone in Cancer Metastasis. J Bone Mineral Res. 2008;1-15.

Heindel W, Gübitz R, Vieth V, Weckesser M, Schober O, Schäfers M. The Diagnostic Imaging of Bone Metastases. Deutsches Ärzteblatt Int. 2014;111(741):7.

Takagi T, Katagiri H, Kim Y, Suehara Y, Kubota D, Akaike K, et al. Skeletal Metastasis of Unknown Primary Origin at the Initial Visit: A Retrospective Analysis of 286 Cases. PLoS One. 2015;10(6):e0129428.

Haider MT, Taipaleenmäki H. Targeting the Metastatic Bone Microenvironment by MicroRnAs. Front Endocrinol. 2018;9(202).

Souza F, Aguilera A, Chaitowitz I, Subhawong K. Diagnostic and Interventional Radiology Considerations in Metastatic Bone Disease. Operative Tech Orthop. 2021;31(3).

Daniela E. Bone Metastases Are Measurable: The Role of Whole-Body MRI and Positron Emission Tomography. Front Oncol. 2021;11.

Ardakani AHG. Metastatic Bone Disease: Early Referral for Multidisciplinary Care. Cleveland Clin J Med. 2022;89:7.

Subalakshmi B, Nellaiyappan B, Thanka J. Analysis of Metastatic Bone Disease in A Tertiary Care Centre. Indian J Pathol Oncol. 2018;5(3):505-8.

Sullivan GJ, Carty FL, Cronin CG. Imaging of bone metastasis: An update. World J Radiol. 2015;7(8):202-11.

Rincon JO. Review of Imaging Techniques for Evaluating Morphological and Functional Responses to The Treatment of Bone Metastases in Prostate and Breast Cancer. Clin Transl Oncol. 2022;24:1290-310.

Isaac A, Dalili D, Dalili D, Weber MA. State-Of-The-Art Imaging for Diagnosis of Metastatic Bone Disease. Radiologe. 2020;60(1):1-16.

Carlson P.Targeting The Perivascular Niche Sensitizes Disseminated Tumour Cells to Chemotherapy. Nat Cell Biol. 2019;21(2):238-50.

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Published

2023-01-23

Issue

Section

Case Reports