An interesting case of pyrexia of unknown origin
DOI:
https://doi.org/10.18203/2349-3933.ijam20230068Keywords:
Kikuchi, Brucellosis, Pyrexia of unknown originAbstract
Pyrexia of unknown origin (PUO) is defined as fever≥101°F on at least two occasions, illness duration of ≥3 weeks. Brucellosis is a bacterial infection caused by brucella species that includes Brucella canis, Brucella abortus, Brucella melitensis, and Brucella suis. They are gram-negative coccobacilli. They are non-motile, non-spore-forming, and facultative intracellular organisms. Kikuchi disease is a benign self-limiting disease, also referred to as histiocytic necrotizing lymphadenitis. Kikuchi disease mainly affects young women and usually presents as fever, lymphadenopathy and leucopenia. The manifestations are similar to brucellosis. Both coexist in a patient, which can be challenging for the treating physician. Here, we presented a case of brucellosis with coexisting Kikuchi disease.
References
Bleeker-Rovers C, Meer J. Fever of Unknown origin. Harrison’s principles of internal medicine. New York, NY: McGraw Hill; 2016: 135.
Hayoun MA, Muco E, Shorman M. Brucellosis. Treasure Island, FL: StatPearls Publishing; 2022.
Moreno E, Moriyon I. Brucella melitensis: a nasty bug with hidden credentials for virulence. Proc Natl Acad Sci U S A. 2002;99(1):1-3.
Mahajan T, Merriman RC, Stone MJ. Kikuchi-Fujimoto disease (histiocytic necrotizing lymphadenitis): report of a case with other autoimmune manifestations. Proc (Bayl Univ Med Cent). 2007;20(2):149-51.
Supari D, Ananthamurthy A. Kikuchi-fujimoto disease: a study of 24 cases. Indian J Otolaryngol Head Neck Surg. 2014;66(1):69-73.
Hossain AK, Datta PG, Amin AS, Uddin MJ. Kikuchi-Fujimoto Disease presenting with fever, lymphadenopathy and dysphagia. J Pak Med Assoc. 2008;58(11):647-9.
Racette SD, Alexiev BA, Angarone MP, Bhasin A, Lima K, Jennings LJ, et al. Kikuchi-Fujimoto disease presenting in a patient with SARS-CoV-2: a case report. BMC Infect Dis. 2021;21(1):740.
Das A, Bhave SJ, Pal B, Arun I, Goel G, Bhattacharya S, et al. Brucellosis Complicated by Kikuchi-Fujimoto Disease and Doxycycline-Induced Intracranial Hypertension. Indian J Pediatr. 2019;86(11):1063-4.
Wheeler ND, Raval MR, Swerdlow SH, Modi S, Liang K, Domsic RT. A case of brucellosis associated with histiocytic necrotizing lymphadenitis: a diagnostic pitfall. J Interdiscipl Histopathol. 2013;1(5):274-9.
Pandit DP, Pandit PT. Human Brucellosis: Are we neglecting an enemy at the backyard. Med J DY Patil Univ 2013;6:350-8.
