Prevalence of pulmonary function abnormalities in type 2 diabetes mellitus and its association with HbA1c in nonsmokers


  • Suman Sarkar Department of Medicine, KPC Medical College and Hospital, Kolkata, West Bengal, India
  • Nirmalya Roy Department of Medicine, KPC Medical College and Hospital, Kolkata, West Bengal, India
  • Souvik Barman Department of Medicine, KPC Medical College and Hospital, Kolkata, West Bengal, India



Diabetes mellitus, Hemoglobin, PFTs, Macrovascular


Background: Diabetes mellitus is a chronic metabolic disorder with vast social and economic consequences an ageing population and obesity due to sedentary lifestyle are one of the foremost reasons for the development of type 2 diabetes mellitus. Aim of the current study was to ascertain the burden of respiratory function abnormalities in type 2 diabetic subjects and its correlation with symptom and hba1c in non-smokers.

Methods: This cross-sectional study was conducted in KPC medical college, Jadavpur. Patients of type 2 diabetes mellitus between the age of 30-80 years fulfilling the modified Borg dyspnoea scale were included after excluding heart failure, COPD, musculoskeletal disorders. The selected subjects were then subjected to a PFT with reversibility and DLCO assessment Pattern of PFT abnormality recorded. Total of 65 subjects were chosen for the study.

Results: In our study most of the patients had Restrictive abnormality Female 24 (42.9%) and male 32 (57.1%). Rest 3 (50.0%) Female patients and 3 (50.0%) male patients had Mixed abnormality. 2 (66.7%) female patients and 1 (33.3%) male patient had normal abnormality which was not statistically significant (p=0.6939).

Conclusions: Pulmonary function is reduced in type 2 diabetes. Diabetes duration seems a more important influence than glycaemic control, but the definitive direction as well as the exact pathophysiological mechanism to explain this association requires further investigation.


Klein OL, Krishnan JA, Jlick S, Smith LJ. Systematic review of association between lung function and type 2 diabetes mellitus. Diabet Med. 2010;27:977-87.

Sandler M. Is the lung is target organ in diabetes mellitus? Arch Intern Med. 1990;150:1385-8.

Sampol G, Lecube A. Type 2 diabetes and the lung: a bidirectional relationship. Endocrinol Nutr. 2012; 59(2):95-7.

Yeh HC, Punjabi NM, Wang NY, Pankow JS, Duncan BB, Cox CE, et al. Cross-sectional and prospective study of lung function in adults with type 2 diabetes: the atherosclerosis risk in communities (ARIC) study. Diab Care. 2008;31(4):7741-6.

Nemagouda SK. Spirometrie abnormalities in patients with type 2 diabetes mellitus. J Evol Med Dent Sci. 2019;8(40):3014-9.

Benbassat CA, Stern E, Blum I, Kramer M, Lebzelter J, Fink G. Pulmonary function in patients with diabetes mellitus. Am J Med Sci. 2001;322(3):127-32.

Chidri SV, Vidya G. Assessment of pulmonary functions in type 2 diabetes mellitus: Its correlation with glycemic control and body mass index. Nat J Physiol Pharm Pharmacol. 2020;10(7):553-6.

Saxena T, Joshi P. Effect of duration of diabetes on pulmonary functions in non- smoker type-2 diabetes mellitus. Nat J Physiol Pharm Pharmacol. 2020;10(8): 645-9.

Acharya PR, D’Souza M, Anand R, Kotian SM. Pulmonary function in type 2 diabetes mellitus: correlation with body mass index and glycemic control. Int J Sci Study. 2016;3(11):18-23.

Rani RE, Ebenezer BI, Venkateswarlu M. A study on pulmonary function parameters in type 2 diabetes mellitus. Nat J Physiol Pharm Pharmacol. 2019;9(1): 53-7.






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