Evaluation of platelet indices in dengue fever in a tertiary care hospital in Bangladesh


  • Debatosh Paul Department of Laboratory Medicine, Bangabandhu Sheikh Mujib Medical University, Dhaka, Bangladesh
  • Amit K. Pramanik Department of Transfusion Medicine, Rajshahi Medical College Hospital, Rajshahi, Bangladesh
  • Sanchita Biswas Department of Paediatrics, Dhaka National Medical College, Dhaka, Bangladesh
  • Chitra Das Department of Biochemistry, Mymensingh Medical College, Mymensingh, Bangladesh
  • Mohammad T. Islam Department of Internal Medicine, Bangabandhu Sheikh Mujib Medical University, Dhaka, Bangladesh




Dengue fever, Platelet indices, MPV, PDW


Background: Dengue fever is the most rapidly spreading mosquito-borne viral diseases in the world. Some evidence suggests that platelet indices may have diagnostic and prognostic value in Dengue fever. The aim of the study is to evaluate platelet indices and to find their correlation between platelet count in Dengue fever.

Methods: This retrospective cross-sectional study was conducted through the use of stored data in Bangabandhu Sheikh Mujib Medical University (BSMMU) dengue cell from July 2019 to September 2019 at department of laboratory medicine and department of internal medicine, BSMMU, Dhaka. Among them, clinical records of 260 cases are preserved in a structured clinical record form (CRF). After ethical clearance from institutional review board (IRB), form clinical records of 260 cases which were preserved in a structured CRF patients who fulfilled the inclusion and exclusion criteria was selected as study population.

Results: Platelet indices (MPV and PDW) were statistically significant difference among different platelet counts (p<0.05). There was significant negative correlation between platelet count and PDW (r=-0.228, p≤0.001). There was also negative correlation between platelet count and MPV (r=-0.106) which was not statistically significant (p=0.088).

Conclusions: Platelet indices are useful parameters in dengue infection. Other than platelet count, PDW and MPV are useful to monitor dengue fever.


Thomas SJ, Strickman D, Vaughn DW. Dengue epidemiology: virus epidemiology, ecology, and emergence. Adv Virus Res. 2003;61:235-89.

Simmons CP, Farrar JJ, van Vinh Chau N, Wills B. Dengue. N Engl J Med. 2012;366(15):1423-32.

Ahmed FU, Mahmood CB, Sharma JD, Hoque SM, Zaman R, Hasan MS. Dengue and Dengue Haemorrhagic Fever in children during the 2000 outbreak in Chittagong, Bangladesh. Available at: https://apps.who.int/iris/handle/10665/163693. Accessed on 12 December 2022.

Shirin T, Muraduzzaman AK, Alam AN, Sultana S, Siddiqua M, Khan MH, et al. Largest dengue outbreak of the decade with high fatality may be due to reemergence of DEN-3 serotype in Dhaka, Bangladesh, necessitating immediate public health attention. New microbes and new infections. 2019;29.

Guabiraba R, Ryffel B. Dengue virus infection: current concepts in immune mechanisms and lessons from murine models. Immunology. 2014;141(2):143-56.

Chuang YC, Lin YS, Liu CC, Liu HS, Liao SH, Shi MD, et al. Factors contributing to the disturbance of coagulation and fibrinolysis in dengue virus infection. J Formosan Med Assoc. 2013;112(1):12-7.

Vagdatli E, Gounari E, Lazaridou E, Katsibourlia E, Tsikopoulou F, Labrianou I. Platelet distribution width: a simple, practical and specific marker of activation of coagulation. Hippokratia. 2010;14(1):28.

Wiwanitkit V. Mean platelet volume in the patients with dengue hemorrhagic fever. Platelets. 2004;15(3):185.

Zhang S, Cui YL, Diao MY, Chen DC, Lin ZF. Use of platelet indices for determining illness severity and predicting prognosis in critically ill patients. Chinese Med J. 2015;128(15):2012.

Khansili S, Bansal NK. Evaluation of correlation between mean platelet count and orther platelet indices with dengue fever. Indian J Res. 2019;8(4):40-2.

Mukker P, Kiran S. Platelet indices evaluation in patients with dengue fever. Int J Res Med Sci. 2018;6(6):2054-9.

Nehara HR, Meena SL, Parmar S, Gupta BK. Evaluation of platelet indices in patients with dengue infections. Int J Sci Res. 2016;5(7):78-81.

Meena VK, Bihari S, Meena SR. Diagnostic significance of platelet indices in dengue fever in endemic area. Int J Res Rev. 2020;7(2):315-9.

Prakash GM, Anikethana GV. Use of mean platelet volume and platelet distribution width in predicting trend in platelet count and bleeding risks in patients of dengue fever. Int J Adv Med. 2016;3:611-3.

Bashir AB, Mohammed BA, Saeed OK, Ageep AK. Thrombocytopenia and bleeding manifestations among patients with dengue virus infection in Port Sudan, Red Sea State of Sudan. J Infect Dis Immunity. 2015;7(2):7-13.

Babu E, Basu D. Platelet large cell ratio in the differential diagnosis of abnormal platelet counts. Indian J Pathol Microbiol. 2004;47(2):202-5.

Kaito K, Otsubo H, Usui N, Yoshida M, Tanno J, Kurihara E, et al. Platelet size deviation width, platelet large cell ratio, and mean platelet volume have sufficient sensitivity and specificity in the diagnosis of immune thrombocytopenia. Br J Haematology. 2005;128(5):698-702.

Bowles KM, Cooke LJ, Richards EM, Baglin TP. Platelet size has diagnostic predictive value in patients with thrombocytopenia. Clin Lab Haematol. 2005;27(6):370-3.

Khandal A. MPV and Dengue. IJIRAS. 2017;4(6).

Khaleel KJ, Ahmed AA, Alwash A, Anwar A. Platelet indices and their relations to platelet count in hypoproductive and hyper-destructive Thrombocytopenia. Karbala J Med. 2014;7(2):1952-8.






Original Research Articles