Deep vein thrombosis as a rare complication of scrub typhus
Keywords:Scrub typhus, Endothelial injury, DVT
Scrub typhus is a common re-emerging, acute febrile infectious disease, caused by orientia tsutsugamushi, transmitted by bite of chiggers of trombiculid mite. The clinical presentation of infection can vary from mild symptoms to severe multi organ failure, shock, encephalopathy, meningoencephalitis, DIC and various thromboembolic complications. We describe a rare hematological complication of deep vein thrombosis (DVT) caused by scrub typhus in a 61-year-old female. Vasculitis and perivasculitis with endothelial dysfunction could be considered as the main pathologic mechanism causing this complication.
Diagnosis GFOR, Rickettsial MOF. Guidelines for diagnosis and management of Rickettsial diseases in India. 2015;1.
Kim JJ. Studies on Rickettsial isolation and serological tests for the diagnosis of Tsusugamushi disease. Kor J Clin Pathol. 1992;12:49-65.
Mathai E, Rolain JM, Verghese GM. Outbreak of scrub typhus in southern India during the cooler months. Ann N Y Acad Sci. 2003;990:359-64.
HD. Pathologic study of thirty-one cases of scrub typhus fever with especial reference to the cardiovascular system. Am Heart J. 1946;31:314-28.
Valbuena G, Walker DH. Infection of the endothelium by members of the order Rickettsiales. Thromb Haemost 2009;102:1071-9.
Elghetany MT, Walker DH. Hemostatic Changes in Rocky Mountain Spotted Fever and Mediterranean Spotted Fever. Am J Clin Pathol. 1999;112:159-68.
Levine HD. Pathologic study of thirty-one cases of scrub typhus fever with especial reference to the cardiovascular system. Am Heart J. 1946;31:314-28.
Honnutagi RM, Reddy KS, Biradar MS. Deep vein thrombosis-a complication of Rickettsial fever. Int J Res Rev. 2019; 6(8):177-80.
Chowdhury S, Mukherjee R, Sinha PK. Novel occurrence of Acute Ischaemic Stroke and DVT simultaneously in a patient of Scrub Typhus: A Case report. Asian J Med Sci. 2020;11(4):91-3.
Mounika C, Praneetha GD, Krishnan D, Maylinanthi K, Vijayakumari V. A Rare Case of Pulmonary Thromboembolism and Acute Respiratory Distress Syndrome (ARDS) in Scrub Typhus. J Commun Dis. 2022;54(1):36-40.
Biswas U, Ghosh R, Chakraborty A, Mondal SR, Roy D, Bhattacharjee A, Roy D, Benito-León J. Cerebral Venous Sinus Thrombosis Following Scrub Typhus Infection: A Case Report and a Review of the Literature. Med Res Arch. 2022;10(10):10.18103/mra.v1.
Das S, Chattopadhyay S, Munsi K. Cerebral Venous Sinus Thrombosis Following Scrub Typhus Infection: A Case Report and a Review of the Literature. BMJ Case Rep. 2021;14:e241401.