Clinical profile and treatment outcome in gastrointestinal cancer patients: a single-center experience in Kashmir valley, India
DOI:
https://doi.org/10.18203/2349-3933.ijam20230702Keywords:
Cancer, GI, Follow up study, Stomach cancerAbstract
Background: Gastrointestinal (GI) cancers are one of the common cancers and are associated with significant morbidity and mortality. The present study was conducted to evaluate the treatment outcome of GI cancer patients undergoing follow-up in the oncology OPD of a tertiary care hospital.
Methods: Cases previously treated for any GI cancer at one center and coming for follow-up to the hospital were enrolled. Treatment outcome was ascertained in these patients and its relationship with clinical and demographic characteristics of patients at diagnosis were analysed.
Results: A total of 68 cases of GI cancers were enrolled with a mean age of 57.44±8.3 years and of 39 (57.35%) were males. The most common site for cancers was oesophagus, stomach, Colo-rectal with 22,20 and 17 cases respectively. Stage II was the most common stage at presentation in 50% cases followed by Stage III in 32.35% of cases. There was significant association between stage at diagnosis with stage I disease at diagnosis significantly related to complete cure. Site of cancer, age and smoking history had no significant correlation with treatment outcome.
Conclusions: Diagnosis of GI cancers at early stage was associated with complete cure at follow up. This finding demonstrates the importance of early screening for GI cancers and the need to have robust screening guidelines and improving access to screening with highly valid tests particularly for individuals with high risk features.
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References
Sharma A. Gastrointestinal cancers in India: Treatment perspective Time is Ripe for Introspection. South Asian J Cancer. 2016;05(03):125-6.
Weng MT, Chiu YT, Wei PY, Chiang CW, Fang HL, Wei SC. Microbiota and gastrointestinal cancer. J Formos Med Assoc. 2019;118(1):S32-41.
Sung H, Ferlay J, Siegel RL, Laversanne M, Soerjomataram I, Jemal A et al. Global Cancer Statistics 2020: GLOBOCAN Estimates of Incidence and Mortality Worldwide for 36 Cancers in 185 Countries. CA Cancer J Clin. 2021;71(3):209-49.
International Agency for Research on Cancer. Global Cancer Observatory: Cancer Today. 2020. Available at: https://gco.iarc.fr/today. Accessed on 12 January, 2023.
Dhillon PK, Mathur P, Nandakumar A, Fitzmaurice C, Kumar GA, Mehrotra R et al. The burden of cancers and their variations across the states of India: the Global Burden of Disease Study 1990-2016. Lancet Oncol. 2018;19(10):1289-306.
Behera P, Patro BK. Population based cancer registry of India-the challenges and opportunities. Asian Pacific J Cancer Prevention. 2018;19(10):2885-9.
Shakuntala TS, Krishnan SK, Das P, Sudarshan KL, Kotian CM, Santhappan S et al. Descriptive Epidemiology of Gastrointestinal Cancers: Results from National Cancer Registry Programme, India. Asian Pacific J Cancer Prevention. 2022;23(2):409-18.
Sharma A. Gastrointestinal cancers in India: Treatment perspective Time is Ripe for Introspection. South Asian J Cancer. 2016;05(03):125-6.
Arnold M, Sierra MS, Laversanne M, Soerjomataram I, Jemal A, Bray F. Global patterns and trends in colorectal cancer incidence and mortality. Gut. 2017;66(4):683-91.
Yasemi M, Ahmadi MRH, Peyman H, Yasemi MR, Khajavikhan J, Hemati K. A 7-Years Retrospective Study of Gastrointestinal Cancers Incidence in the Western Iran. J Clin Diagn Res. 2015;9(7):EC01.
Shaukat A, Kahi CJ, Burke CA, Rabeneck L, Sauer BG, Rex DK. ACG Clinical Guidelines: Colorectal Cancer Screening 2021. Am J Gastroenterol. 2021;116(3):458-79.
Chatila R, Mansour J, Mugharbil A, Nsouli G, O’Son L, Sayad E et al. Epidemiology and Survival of Colorectal Cancer in Lebanon: A Sub-National Retrospective Analysis. Cancer Control. 2021;28.
Milano AF. 20-Year Comparative Survival and Mortality of Cancer of the Stomach by Age, Sex, Race, Stage, Grade, Cohort Entry Time-Period, Disease Duration and Selected ICD-O-3 Oncologic Phenotypes: A Systematic Review of 157,258 Cases for Diagnosis Years 1973-2014: (SEER*Stat 8.3.4). J Insur Med. 2019;48(1):5-23.
Kim G, Qin J, Hall CB. Association Between Socioeconomic and Insurance Status and Delayed Diagnosis of Gastrointestinal Cancers. J Surgical Res. 2022;279:170-86.
Yalcin S, Philip PA, editors. Textbook of Gastrointestinal Oncology. Springer Nature; 2019.
Dizdar Ö, Kılıçkap S. Global Epidemiology of Gastrointestinal Cancers. Textbook of Gastrointestinal Oncol. 2019;1-12.
Khaliq R, Iqbal P, Kuchay S, Pandurangan AK. Strong association and effect of lifestyle and clinicopathological risk factors in colorectal cancer during treatment process: a study based on Kashmiri population. Toxicol Environmental Heal Sci. 2020;13(1):73-81.
Singh M. Prevalence and distribution of tobacco intake in various districts of Jammu and Kashmir, J and K. J Integrative Med Public Heal. 2022;1(1):10.
National Family Health Survey (NFHS) - main.mohfw.gov.in. Available at: https://main. mohfw.gov.in/sites/default/files/NFHS%20Brief.pdf. Accessed on 20 March 2023.
Qurieshi MA, Khan SMS, Masoodi MA, Qurieshi U, Ain Q, Jan Y et al. Epidemiology of Cancers in Kashmir, India: An Analysis of Hospital Data. Adv Prev Med. 2016;2016:1-6.
Rasool MT, Lone MM, Wani ML, Afroz F, Zaffar S, Mohib-Ul Haq M. Cancer in Kashmir, India: Burden and pattern of disease. J Cancer Res Ther. 2012;8(2):243.
Arnold M, Abnet CC, Neale RE, Vignat J, Giovannucci EL, McGlynn KA et al. Global Burden of 5 Major Types of Gastrointestinal Cancer. Gastroenterology. 2020;159(1):335-349.e15.
Mathur P, Sathishkumar K, Chaturvedi M, Das P, Sudarshan KL, Santhappan S et al. Cancer Statistics, 2020: Report From National Cancer Registry Programme, India. JCO Glob Oncol. 2020;6(6):1063-75.
Younis M, Qadri AI, Vane A, Yousuf A, Bhat MH. Clinicopathological profile and operative outcomes of gastric cancer patients in Kashmir: a high incidence area. Int J Res Med Sci. 2022;10(3):617.
Wang S, Xu L, Wang Q, Li J, Bai B, Li Z. Postoperative complications and prognosis after radical gastrectomy for gastric cancer: A systematic review and meta-analysis of observational studies. World J Surg Oncol. 2019;17(1):1-10.
Rawla P, Barsouk A. Epidemiology of gastric cancer: global trends, risk factors and prevention. Gastroenterol Rev/ Przegląd Gastroenterologiczny. 2018;14(1):26-38.
Gupta S. Screening for Colorectal Cancer. Hematol Oncol Clin North Am. 2022;36(3):393-414.
Knudsen AB, Zauber AG, Rutter CM, Naber SK, Doria-Rose VP, Pabiniak C et al. Estimation of benefits, burden, and harms of colorectal cancer screening strategies: Modeling study for the US preventive services Task Force. JAMA. 2016;315(23):2595-609.
National Programme for Prevention and Control of Cancer, Diabetes, Cardiovascular diseases and Stroke (NPCDCS), Ministry of Health and Family Welfare, GOI. Available at: https://main.mohfw.gov.in/Major-Programmes/non-communicable-diseases-injury-trauma/Non-Communicable-Disease-II/National-Programme-for-Prevention-and-Control-of-Cancer-Diabetes-Cardiovascular-diseases-and-Stroke-NPCDCS. Accessed on 19 January, 2023.
