Study of serum lipid profile in patients with chronic liver disease and its correlation with child Pugh class: a hospital based observational study in North Indian patients

Authors

  • Ajit Kumar Verma Department of Medicine, GSVM Medical College, Kanpur, Uttar Pradesh, India
  • Shri Krishna Gautam Department of Medicine, GSVM Medical College, Kanpur, Uttar Pradesh, India
  • Richa Giri Department of Medicine, GSVM Medical College, Kanpur, Uttar Pradesh, India
  • J. S. Kushwaha Department of Medicine, GSVM Medical College, Kanpur, Uttar Pradesh, India
  • Vishal Gupta Department of Medicine, GSVM Medical College, Kanpur, Uttar Pradesh, India
  • Reena Singh Department of Medicine, GSVM Medical College, Kanpur, Uttar Pradesh, India

DOI:

https://doi.org/10.18203/2349-3933.ijam20231074

Keywords:

Chronic liver disease, CTP score, Serum lipid profile

Abstract

Background: Liver disease impacts on hepatic synthesis of lipoproteins and lipogenesis but data on dyslipidemia during disease progression are limited. We want assess the patterns of dyslipidemia in with different etiology liver disease and its correlation with Child Pugh score from non-advanced (non-ACLD) advanced chronic liver disease (ACLD) as it is unclear how progression to ACLD impacts on dyslipidemia-associated cardiovascular risk. Aim and objectives of current study were to determine serum lipid profile in patients with chronic liver disease and its correlation with Child Pugh score.

Methods: It was Cross sectional, observational study conducted in 200 patients at KPS post graduate institute of medicine, GSVM medical college, Kanpur from December 2020 to October 2022.

Results: In this study mean value of Serum Cholesterol (mg/dl) was 135.25 (27.88), Serum Triglycerides (mg/dl) was 122.27 (36.29), HDL Cholesterol was 46.92 (10.36), LDL Cholesterol was 62.77 (22.59), VLDL Cholesterol was 25.62 (8.71). In this study maximum patients of chronic liver disease were due to chronic alcohol intake which account for 76% patients, 2nd most common aetiology of chronic liver disease were chronic viral hepatitis and rest were due to Wilson disease, Budd Chiari syndrome non cirrhotic portal fibrosis and cryptogenic. Patients of chronic liver disease have negative correlation on lipid profile with Child Pugh score.

Conclusions: From our study its was concluded that patients having higher CTP score having more derangement (low) in serum lipid profile (specially) serum cholesterol, serum HDL, serum VLDL) than the patients having low CTP score.

References

Jatav JK, Shakya RK, Singh S. Study of lipid profile changes in cirrhosis of liver. Int J Sci Study. 2018;6(3): 187.

Unger LW, Forstner B, Schneglberger S, Muckenhuber M, Eigenbauer E, Scheiner B, et al. Patterns and prevalence of dyslipidemia in patients with different etiologies of chronic liver disease. Wien Klin Wochenschr. 2019;131:395-403.

Derbak M, Boldizhar P. Correction of dyslipidemia in patients with chronic hepatitis C, combined with diabetes type 2. Georgian Med News. 2014;(226):25-31.

Tauseef A, Zafar M, Rashid B, Thirumalareddy J, Chalfant V, Farooque U, Mirza M. Correlation of fasting lipid profile in patients with chronic liver disease: a descriptive cross-sectional study in tertiary care hospital. Cureus. 2020;12:0.

Serum lipid profile in alcoholic cirrhosis: a study in a teaching hospital of north-eastern India. Phukan JP, Sinha A, Deka JP. Niger Med J. 2013;54:5-9.

Qazi F, Khan SB, Umar A, Shaikh NS. Changes in serum lipid profile among patients suffering from chronic liver disease secondary to hepatitis C. Int J Sci Study. 2012;32:105.

Unger LW, Forstner B, Schneglberger S. Patterns and prevalence of dyslipidemia in patients with different etiologies of chronic liver disease. Wien Klin Wochenschr. 2019;131:395-403.

Subhan F, Khan I, Arif R, Khan A, Khan A. Serum lipid profile as an indicator of the severity of liver damage in cirrhotic patients. Int J Sci Study. 2014;23: 45-9.

Ghadir MR, Riahin AA, Havaspour A, Nooranipour M, Habibinejad AA. The relationship between lipid profile and severity of liver damage in cirrhotic patients. Int J Sci Study. 2016;41:45-9.

Deeb A, Attia S, Mahmoud S, Elhaj G, Elfatih A. Dyslipidemia and fatty liver disease in overweight and obese children. J Obes. 2018;2018:862.

Sohail S, Mustafa MI, Shaheen MA, Ali QM, Tariq MS. Dyslipidemia and mean lipid profile in patients with liver cirrhosis. Int J Res Med Sci. 2020;8:1658-61.

Downloads

Published

2023-04-26

Issue

Section

Original Research Articles