Sudden infant death syndrome


  • Basel Abdulrahman Almansoor Department of Pediatrics, Qassim University, Unaizah, Kingdom of Saudi Arabia
  • Waleed Ahmed Almaiman Unaizah College of Medicine and Medical Sciences, Qassim University, Unaizah, Kingdom of Saudi Arabia



SIDS, Risk factors, Incidence, Prevention


The sudden death of infants younger than one year is known as SIDS. It is a major cause of mortality among infants less than one year of age. There is little focus in the literature on sudden infant death syndrome (SIDS). Thus, this review aims to provide new insights on the incidence, risk factors and prevention of SIDS in infants. Following preferred reporting items for systematic review and meta-analysis (PRISMA) guidelines, this review explored eligible articles from PubMed, Google Scholar, and research gate databases. Several keywords were used for the search to obtain all possible related articles. The inclusion criteria were reviews and original articles focused on the current subject and written in English. The eligible articles used to compile this review were published between 2007 and 2021. Three main titles were discussed in this review: incidence, risk factors, and prevention. SIDS is the most common reason for death among infants aged less than one year. There is great variation in the global incidence of SIDS. Factors related to the sleeping environment are the major risk factors for SIDS and should be the focus. Hence, following the recommendations of the American academy of pediatrics can reduce incidence of SIDS.


Imhof R, Imhof N, Wasnick R, Khan SA. Current concepts of sudden infant death syndrome: A review of literature. Archivos de Med. 2015;6(4):35.

Horne RS. Sudden infant death syndrome: current perspectives. Internal Med J. 2019;49(4):433-8.

Adams SM, Ward CE, Garcia KL. Sudden infant death syndrome. Am Family Physician. 201;91(11):778-83.

Van Nguyen JM, Abenhaim HA. Sudden infant death syndrome: review for the obstetric care provider. Am J Perinatol. 2013;30:703-14.

Goldwater PN. A perspective on SIDS pathogenesis. the hypotheses: plausibility and evidence. BMC Med. 2011;9:64.

Moon RY. Task Force on Sudden Infant Death Syndrome. SIDS and other sleep-related infant deaths: expansion of recommendations for a safe infant sleeping environment. Pediatrics. 2011;128(5):1030-9.

Krous HF, Beckwith JB, Byard RW, Rognum TO, Bajanowski T, Corey T et al. Sudden infant death syndrome and unclassified sudden infant deaths: a definitional and diagnostic approach. Pediatrics. 2004;114(1):234-8.

Bechtel K. Sudden unexpected infant death: differentiating natural from abusive causes in the emergency department. Pediatr Emerg Care. 2012;28:1085-9.

Moon RY, Horne RS, Hauck FR. Sudden infant death syndrome. Lancet. 2007;370(9598):1578-87.

Maternal and Child Health Statistics of Japan: Boshi Eisei Kenkyuu Kai. 2006.

Central Bureau of Statistics, Netherlands. 2006. Available at: GB. Accessed on 25 January, 2023.

Hoyert DL, Mathews TJ, Menacker F, Strobino DM, Guyer B. Ann Summary Vital Statistics. Pediatrics. 2006;117:168-83.

Report: Unexplained Deaths in Infancy, 2005. Health Stat Q. 2006;82-6.

Moon RY, Fu L. Sudden infant death syndrome: an update. Pediatr Rev. 2012;33(7):314-20.

Franco P, Raoux A, Kugener B, Scaillet S, Groswasser J, Kato I et al. Sudden Infant Death Syndrome: From Epidemiology to Pathophysiology. Encyclopedia of Sleep. 2013:638-44.

Getahun D. Maternal and obstetric risk factors for sudden infant death syndrome in the United States. Obstet Gynecol. 2004;103:646-52.

Mage DT, Donner EM. Is excess male infant mortality from sudden infant death syndrome and other respiratory diseases X-linked? Acta Paediatr. 2014;103:188-93.

Taylor BJ. International comparison of sudden unexpected death in infancy rates using a newly proposed set of cause-of-death codes. Arch Dis Child. 2015;1.

Mathews TJ, Menacker F, MacDorman MF. Centers for Disease Control and Prevention, National Center for Health Statistics. Infant mortality statistics from the 2002 period: linked birth/infant death data set. Natl Vital Stat Rep. 2004;53:1-29.

Rienks J, Oliva G. Using social marketing to increase awareness of the African American infant mortality disparity. Health Promot Pract. 2013;14:408-14.

Centers for Disease Control and Prevention (CDC). CDC grand rounds: public health approaches to reducing U.S. infant mortality. MMWR Morb Mortal Wkly Rep. 2013;62(31):625-8.

Perrone S, Lembo C, Moretti S, Prezioso G, Buonocore G, Toscani G et al. Sudden infant death syndrome: beyond risk factors. Life. 2021;11(3):184.

Osei-Poku GK, Thomas S, Mwananyanda L, Lapidot R, Elliott PA, Macleod WB et al. A systematic review of the burden and risk factors of sudden infant death syndrome (SIDS) in Africa. J Global Heal. 2021;11.

Malloy MH. Prematurity and sudden infant death syndrome: United States 2005-2007. J Perinatol. 2013;33:470-75.

Fu LY, Moon RY, Hauck FR. Bed sharing among black infants and sudden infant death syndrome: interac¬tions with other known risk factors. Acad Pediatr. 2010;10(6):376-82.

O’Leary CM, Jacoby PJ, Bartu A. Maternal alcohol use and sudden infant death syndrome and infant mortal¬ity excluding SIDS. Pediatrics. 2013;131(3):e770-8.

Webb RT, Wicks S, Dalman C. Influence of envi-ronmental factors in higher risk of sudden infant death syndrome linked with parental mental illness. Arch Gen Psychiatr. 2010;67(1):69-77.

Mitchell EA, Ford RP, Stewart AW. Smoking and the sudden infant death syndrome. Pediatrics. 1993;91(5):893-6.

Machaalani R, Say M, Waters KA. Effects of cigarette smoke exposure on nicotinic acetylcholine recep¬tor subunits α7 and β2 in the sudden infant death syndrome (SIDS) brainstem. Toxicol Appl Pharmacol. 2011;257(3):396-404.

Colvin JD, Collie-Akers V, Schunn C. Sleep envi-ronment risks for younger and older infants. Pediatrics. 2014;134(2):e406-12.

Ponsonby A-L, Dwyer T, Gibbons LE, Cochrane JA, Wang Y-G. Factors potentiating the risk of sudden infant death syndrome associated with the prone position. N Engl J Med. 1993;329:377-82.

Fleming P, Gilbert R, Azaz Y. Interaction between bedding and sleeping position in the sudden infant death syndrome: a population-based case-control study. BMJ. 1990;301:85-9.

Ponsonby A-L, Dwyer T, Gibbons LE, Cochrane JA, Jones ME, McCall MJ. Thermal environment and sudden infant death syndrome: case-control study. BMJ. 1992;304:277-82.

Colson ER, Willinger M, Rybin D. Trends and fac-tors associated with infant bed sharing, 1993-2010: the National Infant Sleep Position Study. JAMA Pediatr. 2013;167(11):1032-7.

Vennemann MM, Hense HW, Bajanowski T. Bed sharing and the risk of sudden infant death syndrome: can we resolve the debate? J Pediatr. 2012;160(1):44-8.

Ruys JH, De Jonge GA, Brand R, Engelberts AC, Semmekrot A. Bed-sharing in the first four months of life: A risk factor for sudden infant death. Acta Paediatr. 2007;96:1399-403.

Mage DT, Donner M. A Unifying Theory for SIDS. Int J Pediatr. 2009;368270.

Hauck FR, Herman SM, Donovan M. Sleep environ¬ment and the risk of sudden infant death syndrome in an urban population: the Chicago Infant Mortality Study. Pediatrics. 2003;111(5 pt 2):1207-14.

Carlin RF, Moon RY. Risk factors, protective factors, and current recommendations to reduce sudden infant death syndrome: a review. JAMA Pediatr. 2017;171(2):175-80.

Hauck FR, Thompson JM, Tanabe KO, Moon RY, Vennemann MM. Breastfeeding and reduced risk of sudden infant death syndrome: a meta-analysis. Pediatrics. 2011;128(1):103-10.

Oliveira AM, Andrade PR, Pinheiro EM, Avelar AF, Costa P, Belela-Anacleto AS. Risk and protective factors for sudden infant death syndrome. Revista Brasileira de Enfermagem. 2020;73.

Alm B,Wennergren G, Mollborg P, Lagercrantz H. Breastfeeding and dummy use have a protective effect on sudden infant death syndrome. Acta Paediatr. 2016;105(1):31-8.

Yiallourou SR, Poole H, Prathivadi P, Odoi A, Wong FY, Horne RS. The effects of dummy/pacifier use on infant blood pressure and autonomic activity during sleep. Sleep Med. 2014;15(12):1508-16.

McDonnell E, Moon RY. Infant deaths and injuries associ¬ated with wearable blankets, swaddle wraps, and swad¬dling. J Pediatr. 2014;164(5):1152-6.






Review Articles