A rare complication of a relatively common disease: periodic paralysis caused by thyrotoxicosis

Authors

  • Abhishek Chanda Department of Medicine, KPC Medical College and Hospital, Kolkata, West Bengal, India
  • Mainak Mandal Department of Medicine, KPC Medical College and Hospital, Kolkata, West Bengal, India
  • Suman Sarkar Department of Medicine, KPC Medical College and Hospital, Kolkata, West Bengal, India
  • Nirmalya Roy Department of Medicine, KPC Medical College and Hospital, Kolkata, West Bengal, India

DOI:

https://doi.org/10.18203/2349-3933.ijam20231880

Keywords:

Thyrotoxicosis, Periodic paralysis, Hypo-kalemia

Abstract

Thyrotoxic periodic paralysis is a sporadic form of hypo-kalemic periodic paralysis and it is most commonly presents as sudden onset weakness in the proximal muscles. It is a disorder most commonly seen in Asian men which is characterised by abrupt onset of hypo-kalemia and paralysis and it is primarily affects lower extremities and is secondary to thyrotoxicosis. It is due to an intracellular shift of potassium induced by thyroid hormone sensitisation of Na/K ATPase rather than depletion of total potassium. The absence of a family history, male predilection and, presentation in second to fourth decade of life and signs of thyrotoxicosis and sinus tachycardia help in the diagnosis of the disorder. The age of onset is later and corresponded with age of incidence of thyrotoxicosis. It is very essential to diagnose TPP early and treat appropriately.

References

Tella SH, Kommalapati A. Thyrotoxic Periodic Paralysis: An Underdiagnosed and Under-recognized condition. Cereus. 2015;7(10):e342.

Siddamreddy S, Dandu V. Thyrotoxic Periodic Paralysis. In: StatPearls. 2022.

McFadzean AJ, Yeung R. Periodic paralysis complicating thyrotoxicosisin Chinese. Br Med J. 1967;1(5538):451-5.

Abhishek V. Thyrotoxic Periodic Paralysis: Clinical Challenges. J Thyroid Res. 2014;649502.

Lien L, Rajasree JN. Thyrotoxic periodic paralysis. Proc (Bayl Univ Med Cent. 2006;19(2):126-9.

Ludgate S. Thyrotoxic periodic paralysis associated with Graves’ disease: a case series, In endocrinology. Diabetes Metabolism Case Rep. 2022:1:10.

Pothiwala P, Levine SN. Analytic review: thyrotoxic periodic paralysis: a review. J Intensive Care Med. 2010,25:71-7.

Ober KP. Thyrotoxic periodic paralysis in united states. Report of 7 cases and review of the literature. Medicine (Baltimore). 1992;71:109-20.

Kung AWC. Thyrotoxic Periodic Paralysis: A diagnostic Challenge. J Clin Endocrinol Metabolism. 2006;91(7):2490-95.

Jackson I. Hypokalemic Periodic Paralysis Precipitated by Thyrotoxicosis and Renal tubular Acidosis. Case Reports Endocrinol. 2021;4529009:4.

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Published

2023-06-27

Issue

Section

Case Reports