A study of thyroid function profile in patients of chronic liver disease and its correlation with child Pugh score


  • Richa Giri Department of Medicine, GSVM Medical College, Kanpur, Uttar Pradesh, India
  • Vinay P. Singh Department of Medicine, GSVM Medical College, Kanpur, Uttar Pradesh, India
  • Yuvraj Gulati Department of Medicine, GSVM Medical College, Kanpur, Uttar Pradesh, India
  • Vinay Kumar Department of Medicine, GSVM Medical College, Kanpur, Uttar Pradesh, India




CLD, Thyroid Function, TSH, FT3


Background: Chronic liver disease (CLD) is a continuous process of inflammation, destruction, and regeneration of liver parenchyma, which leads to fibrosis and cirrhosis. Liver plays an essential physiological role in thyroid hormone activation and inactivation, transport, and metabolism, as well as the synthesis of thyroid binding globulin. A complex relationship exists between thyroid and liver in health and disease.

Methods: 103 patients of CLD were included in this study from December 2020 to September 2022. They were classified as per child Pugh scoring after clinical assessment and investigations. Serum TSH, FT3, FT4 levels were measured for all the patients.

Results: Out of 103 patients and it was found that 19 (18.44%) patients belonged CTP class A, 40 (38.83%) patients had CTP score of class B, while maximum 44 (42.71%) patients belonged CTP class C. There was significant positive correlation between CTP class and TSH values (p<0.001) with mean (SD) of CTP class A, B and C were 2.42 (0.76), 3.9 (1.02) and 5.91 (1.08) respectively. There was significant negative correlation between CTP class and FT3 values (p<0.001) and between CTP class and FT4 values (p<0.001).

Conclusions: Our study found that there was significant positive correlation of S.TSH values with severity of CLD as assessed by CTP score, while FT3 and FT4 were having significant negative correlation.


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