Study of correlation of hypothyroidism with diabetic microvascular complications in type 2 diabetic adult Indian females
DOI:
https://doi.org/10.18203/2349-3933.ijam20231876Keywords:
Hypothyroidism, HbA1c, BMI, Microvascular complicationsAbstract
Background: Patients with type 2 diabetes mellitus are more prone to thyroid disorders. Hypothyroidism in them leads to an aggravation of microvascular complications. Screening for thyroid dysfunction in diabetic patients will allow early treatment of hypothyroidism. The aim of this study is to assess the correlation of hypothyroidism with diabetic microvascular complications.
Methods: This is a cross‑sectional study that was conducted at department of medicine GSVM Medical College, Kanpur. 200 female patients with type 2 diabetes mellitus attending the out‑patient department were included. Subjects with any prior history of thyroid disease, chronic liver disease, or acute illness were excluded from the study.
Results: Our study describes 14% prevalence of hypothyroidism (subclinical hypothyroidism 13.5%) among 200 diabetic subjects. Among hypothyroid patients 64.29% patients had nephropathy, 60.71% patients had neuropathy, 64.29% patients had retinopathy whereas euthyroid patients had 26.74%, 25% and 29.07% nephropathy, neuropathy, and retinopathy respectively.
Conclusions: The prevalence of hypothyroidism was 14% among female patients with type 2 diabetes mellitus in this study. Overt hypothyroidism was 0.5 % and subclinical hypothyroidism was more common (13.5%) among the study subjects. Patients having hypothyroidism were more likely to be having diabetic nephropathy, neuropathy, and retinopathy.
References
Demitrost L, Ranabir S. Thyroid dysfunction in type 2 diabetes mellitus: A retrospective study. Indian J Endocrinol Metab. 2012;16:S334 5.
Donckier JE. Endocrine diseases and diabetes. In: Pickup JC, Williams G, editors. Textbook of Diabetes Mellitus. Chicester, U.K.: Blackwell Publishing Company. 2003;21 7.
Ghazali SM, Abbiyesuku FM. Thyroid dysfunction in type 2 diabetics seen at the University College Hospital, Ibadan, Nigeria. Niger J Physiol Sci. 2010;25:173 9.
Chen HS, Wu TE, Jap TS, Lu RA, Wang ML, Chen RL, et al. Subclinical hypothyroidism is a risk factor for nephropathy and cardiovascular diseases in type 2 diabetic patients. Diabet Med. 2007;24:1336 44.
Walsh JP, Bremner AP, Bulsara MK, O’Leary P, Leedman PJ, Feddema P, et al. Subclinical thyroid dysfunction as a risk factor for cardiovascular disease. Arch Intern Med. 2005;165:2467 72.
Perros P, McCrimmon RJ, Shaw G, Frier BM. Frequency of thyroid dysfunction in diabetic patients: Value of annual screening. Diabet Med. 1995;12:622 7.
Wang C. The relationship between type 2 diabetes mellitus and related thyroid diseases. J Diabetes Res. 2013;390534.
Han C, He X, Xia X, Li Y, Shi X, Shan Z, Teng W. Subclinical Hypothyroidism and Type 2 Diabetes: A Systematic Review and Meta-Analysis. PLoS One. 2015;10(8):e0135233.
Wu J, Yue S, Geng J, Liu L, Teng W, Liu L, Chen L. Relationship between Diabetic Retinopathy and Subclinical Hypothyroidism: a meta-analysis. Sci Rep. 2015;5:12212.
Chen HS, Wu TE, Jap TS, Lu RA, Wang ML, Chen RL, Lin HD. Subclinical hypothyroidism is a risk factor for nephropathy and cardiovascular diseases in Type 2 diabetic patients. Diabet Med. 2007;24(12):1336-44.
Zheng YQ, Xue L, Bie MJ, Li XY, Chen D. Analyzation of lipids and hs-CRP level for type 2 diabetic patients with subclinical hypothyroidism. Modern Prev Med. 2012;39:4485-7.
Gurjeet S, Vikas G, Anu Kumar S, Neeraj G. Evaluation of thyroid dysfunction among type 2 diabetic Punjabi population. Adv Biores. 2011;2:3-9.
Anil Kumar R, Lalitha R, Surekha B. Shetty. Double Trouble: an observational study of thyroid dysfunction in South Indian subjects with type 2 diabetes. Int J Med Res Rev. 2017;5(02):156-62.
Chaturvedi S, Nagtilak S, Parashar P, Rastogi A, Gupta A. Thyroid dysfunction and it's relation with Type 2 diabetes mellitus in Meerut. Int J Sci Res. 2016;7:305-7.
