Analytical study of effects of Magnesium sulphate on pressor response during laryngoscopy and intubation

Kiran KN, Shrinivas TR

Abstract


Background: Induction of general anaesthesia and endotracheal intubation for maintenance of airway and prevention of aspiration is carried out frequently by the anesthesiologist in day to day practice. This study was aimed to study the effects of Magnesium sulphate on pressor response during laryngoscopy and intubation.

Methods: It was carried out in 50 patients of both sexes, between the age group of 20-60 years, belonging to ASA physical status grade I and II. Magnesium sulphate 50mg Kg-1 given intravenously 60 seconds before intubation and the pressor response to laryngoscopy and intubation assessed.

Results: Magnesium  sulphate 50mg Kg-1 given intravenously 60 seconds before intubation, attenuated the pressor response to laryngoscopy and intubation to a significant level, except transient mild tachycardia, which at  the end of 5 minutes settled  back to near pre-induction value.

Conclusions: We conclude that magnesium sulphate is superior for attenuation of pressor response to laryngoscopy and intubation.


Keywords


Laryngoscopy, Intubation, Magnesium Sulphate, Pressor Response

Full Text:

PDF

References


Russell WJ, Morris RG, Frewin DB, Drew SE. Changes in plasma catecholamine concentrations during endotracheal intubation. Br J Anaesth. 1981;53(8):837-9.

Derbyshire DR, Chmielewski A, Fell D, Vater M, Achola K, Smith. Plasma catecholamine responses to tracheal intubation. Br J Anaesth. 1983;55(9):855-60.

James MF, Beer RE, Esser JD. Intravenous magnesium sulphate inhibits catecholamine release associated with tracheal intubation. Anesth Analg. 1989:68(6):772-6.

Bedford RF, Feinstein B. Hospital admission blood pressure: A prediction for hypertension following endotracheal intubation. Anesth Analg. 1980 :59(5):367-70.

Prys-Roberts C, Greene LT, Meloche R, Foex P. Studies of anaesthesia in relation to hypertension. II . Haemodynamic consequences of induction and endotracheal intubation. Br J Anaesth. 1971;43(6):531-47.

Lavies NG, Meiklejohn BH, May AE, Achola KJ, Fell D. Hypertensive and catecholamine response to tracheal intubation in patients with pregnancy included hypertension. Br J Anaesth. 1989;63(4):429-34.

Kumar M; Tikle AC . Attenuation of circulatory responses to laryngoscopy and tracheal intubation with metoprolol. Indian Journal of Anaesthesia. 1995;43(6):385-8.

Kolli SC, Misra RK, Misra MN, Misra TR. Use of verapamil for preventing tachycardia and hypertension in response to laryngoscopy and intubation in treated hypertensives. Indian Journal of Anaesthesia. 1987;35(4):271-6.

Mikawa K, Ikegaki J, Maekawa N, Goto R, Kaetsu H, Obara H.The effect of diltiazem on the cardiovascular response to trachea intubation. Anaesthesia. 1990;45(4):289-93.

Crawford DC, Fell D, Achola KJ, Smith G. Effects of alfentanil on the pressor and catecholamine responses to tracheal intubation. Br J Anaesth. 1987;59(6):707-12.

Ruchi, Baljit, Lalita : A double blind study of attenuation on cardiovascular respnses to tracheal intubation; Intravenous buprenorphine Vs. Placebo. Asian archieves of Anaestnesiology and Resuscitation ; 1995; XLII/1: 27-31.

Bijoria K1, Wig J, Bajaj A, Sapru RP. Isosorbide dinitrate spray. Attenuation of cardiovascular responses to laryngoscopy and intubation. Anesthesia. 1992;47(6): 523-6.

13. James MF, Cork RC, Dennett JE. Succinylcholine pretreatment with magnesium sulfate. Anesth Analg. 1986;65(4):373-6.

Stacey MR, Barclay K, Asai T, Vaughan RS. Effects of magnesium sulphate on suxamethonium-induced complications during rapid sequence induction of anaesthesia. Anaesthesia. 1995;50(11):933-6.