Study of age, sex and body mass index wise variation in C-peptide level among urban population of Northern part of Bihar

Rajeev Kumar; Indu Priyadarshini; Alka Goyal; Swarnim Swarn; Sude Kumar  Singh

doi:10.18203/2349-3933.ijam20233885

Authors

Rajeev Kumar Department of Biochemistry, Darbhanga Medical College, Laheriasarai, Darbhanga, Bihar, India https://orcid.org/0000-0002-0822-9059
Indu Priyadarshini Department of Pharmacology, Nalanda Medical College, Patna, Bihar, India https://orcid.org/0000-0002-1698-7634
Alka Goyal Department of Biochemistry, Darbhanga Medical College, Laheriasarai, Darbhanga, Bihar, India https://orcid.org/0000-0001-9513-9635
Swarnim Swarn Department of Biochemistry, Darbhanga Medical College, Laheriasarai, Darbhanga, Bihar, India https://orcid.org/0000-0001-7837-2769
Sude Kumar Singh Department of Biochemistry, Darbhanga Medical College, Laheriasarai, Darbhanga, Bihar, India

DOI:

https://doi.org/10.18203/2349-3933.ijam20233885

Keywords:

Age, Sex, BMI, C-peptide

Abstract

Background: Different factors regulate the insulin level in blood. Earlier C-peptide was considered as by product of insulin biosynthesis and its role in body seems to be negligible. C-peptide at low physiological concentrations mimics the effects of insulin. However, in the presence of elevated level of insulin concentrations concomitant raised level of C-peptide may blunt peripheral effects of insulin age. This study was carried out to verify the age, sex, and BMI wise variation in level of C-peptide among apparently healthy individual and its contribution in fine-tuning of the tissue’s metabolism under different physiological conditions.

Methods: This is a prospective cross-sectional observational study. Estimation of serum c-peptide level was done by solid phase direct sandwich enzyme linked immunosorbent assay (ELISA) kit method. Glucose is estimated by Glucose oxidase peroxidase (GOD-POD) end point colorimetric method and HbA1C was estimated by ion exchange resin method (kit method).

Result: Serum C-peptide level is significantly high in advance age and males in compared to younger age and females respectively. The mean level of serum C-peptide is higher in higher body mass index (BMI) group compared to lower, but this difference is statistically insignificant.

Conclusions: In normal subjects, the level of C-peptide shows positive correlation with age and BMI. Males have higher level of C-peptide in comparison to females. Apart from these variation C-peptide contributes to different biological effects.

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