An observed repeat case of drug reaction with eosinophilia and systemic symptoms syndrome with modified anti-tuberculosis therapy: a case report

Indu Priyadarshini; Akhilesh Thole; Kapil Hazarika; Manik S. Ghadlinge

doi:10.18203/2349-3933.ijam20240365

Authors

Indu Priyadarshini Department of Pharmacology, ABVIMS and Dr. RML Hospital, New Delhi, India https://orcid.org/0000-0002-1698-7634
Akhilesh Thole Department of Dermatology, ABVIMS and Dr. RML Hospital, New Delhi, India https://orcid.org/0009-0001-3799-3558
Kapil Hazarika Department of Pharmacology, ABVIMS and Dr. RML Hospital, New Delhi, India https://orcid.org/0000-0002-1177-4576
Manik S. Ghadlinge Department of Pharmacology, ABVIMS and Dr. RML Hospital, New Delhi, India https://orcid.org/0000-0003-2494-4762

DOI:

https://doi.org/10.18203/2349-3933.ijam20240365

Keywords:

DRESS syndrome, ATT, Modified ATT

Abstract

Drug reaction with eosinophilia and systemic symptoms (DRESS) syndrome, while uncommon, presents a potentially hazardous condition. It is a drug-induced multi‑system immunological hypersensitivity reaction, characterized by the triad of fever, rash, and internal organ involvement. This is a case report of a 60-year-old Indian female who developed a repeat episode of DRESS syndrome following modified anti-tuberculosis therapy (ATT). She had a past history of DRESS syndrome caused by first-line antitubercular drugs. This case report aims to highlight the challenges in managing DRESS syndrome in the context of tuberculosis (TB) treatment, as well as to emphasize the importance of prompt withdrawal of the culprit drugs and immediate initiation of appropriate supportive care. This case report also highlights the high risk of recurrence of DRESS syndrome following the re-administration of the offending medication, especially antitubercular drugs.

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