Systemic lupus erythematous in men with interstitial lung pneumonia: a rare case report


  • I. Gusti Agung Dwi Putri Anjani Sanjiwani General Hospital, Gianyar, Bali, Indonesia
  • I. Wayan Eka Saputra Department of Internal Medicine, Sanjiwani General Hospital, Gianyar, Bali, Indonesia
  • Putu Dyah Widyaningsih Department of Pulmonology, Sanjiwani General Hospital, Gianyar, Bali, Indonesia



Systemic lupus erythematous, Men, Interstitial lung pneumonia


Systemic lupus erythematosus (SLE) is a chronic autoimmune inflammatory disease with unknown etiology and very diverse clinical manifestations, disease course, and prognosis. It is most common in African-American women, the prevalence being 4 per 1000 females. SLE predominantly affects young women, most presenting between 20 and 40 years of age. Male SLE is rare, with only one male patient reported per nine females. Pulmonary involvement in SLE is various. SLE-associated interstitial lung disease (ILD), while rare, is a predictor of poor prognosis. We report a 50-year-old male patient with complaints of shortness of breath, previously diagnosed with systemic lupus erythematous by examination of the antinuclear antibody (ANA) profile. The patient underwent a computed tomography (CT) scan of the thorax and the results showed interstitial lung pneumonia. The patient was given azathioprine and methylprednisolone therapy for Systemic lupus erythematous and ceftriaxone and acetylcysteine ​​for interstitial lung pneumonia.


Baharudin R, Idris NS, Muhammad J, Abdullah WN. A Case Report of Male Systemic Lupus Erythematosus with Antinuclear Antibodies- Negative: A Challenging Diagnosis. Korean J Fam Med. 2022;43:150-4.

Thomas R, Jawad AS. Systemic Lupus Erythematosus: rarer in men than women but more severe. Rheumatology. 2022;10-4.

Dey S, Ofori E, Hutton-Mensah KA, Akutek M, Okine R, Amoaba I, et al. Clinical characteristics of males with systemic lupus erythematosus (SLE) in an inception cohort of patients in Ghana. Ghana Med J. 2019;52(3):2-7.

Acharya S, Aryal R, Yadav R., Shrestha S, Karki R, Jha S. Organizing Pneumonia as an initial presentation in male lupus: A rare case report: Clin Case Rep. 2023;11:e7389.

Tian J, Zhang D, Yao X, Huang Y, Lu Q. Global epidemiology of systemic lupus erythematosus: a comprehensive systematic analysis and modeling study. Ann Rheum Dis. 2023;82:351-6.

Maria S, Josue A, Mario J, Antonio R. Male systemic lupus erythematosus, an overlooked diagnosis. Clin Pract. 2011;1(103):226-7.

Castelino FV, Varga J. Interstitial lung disease in connective tissue disease: evolving concepts of pathogenesis and management. Arthritis Res Therapy. 2010;12:213.

Ferrero G, Chernow K, Karpoff M, Traisak P, Feinstein D, Eid H. An Elderly Gentlemen with Acute Lupus Pneumonitis as the Initial Manifestation of Systemic Lupus Erythematosus. Case Rep Rheumatol. 2021;2692735.

Roszkowska M, Nowakowska A, Wonski J, Plaza M, Zielinska A. Lymphocytic interstitial pneumonia as an extremely rare manifestation of systemic lupus erythematosus. Pol Arch Intern Med. 2021;131(12):16115.

Thomas R, Jawad AS. Systemic Lupus Erythematosus: rare in men than women but more severe. Rheumatology. 2022;43:11-4.

Richter P, Cardoneanu A, Dima N, Bratoiu I, Rezus C, Burli AM, et al. Interstitial Lung Disease in Systemic Lupus Erythematosus and Systemic Sclerosis: How Can We Manage the Challenge? Int J Mol Sci. 2023;24:9388.

Amanda G, Fathana PB, Sutoyo DK. Interstitial Lung Disease in Systemic Lupus Erythematosus. Respir Case Rep. 2019;8(2):40-3.

Akhil S, Sharma S, Kumar D. Male systemic lupus erythematosus: Two distinct presentation. J Family Med Prim Care. 2021;10(10):3910-1.

Toyoda Y, Koyama K, Kawano H, Nishimura H, Kagawa K, Morizumi S, et al. Clinical features of interstitial pneumonia associated with systemic lupus erythematosus. Respir Investig. 2019;57(5):435-43.

Koo SM, Taek Uh S. Treatment of connective tissue disease-associated interstitial lung disease: the pulmonologist’s point of view. Korean J Intern Med. 2017;32(4):600-10.

Depascale R, Del Frate G, Gasparotto M, Manfrè V, Gatto M, Iaccarino L, et al. Diagnosis and management of lung involvement in systemic lupus erythematosus and Sjögren's syndrome: a literature review. Ther Adv Musculoskelet Dis. 2021;13:1759720X211040696.

Fernandez IG, Moriano C, Alvarez ED, Santos CS, Castro CA, Martin MM, et al. Treatment of Interstitial Lung Involvement in Systemic Lupus Erythematosus: Experience in A Third Level. Ann Rheumat Dis. 2021;8(1):1.

Aguilera-Pickens G, Abud-Mendoza C. Pulmonary Manifestations in Systemic Lupus Erythematosus: Pleural Involvement, Acute Pneumonitis, Chronic Interstitial Lung Disease and Diffuse Alveolar Hemorrhage. Clin Rheumatol. 2018;14(5):294-300.






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