A febrile thrombocytopenia is it always dengue
DOI:
https://doi.org/10.18203/2349-3933.ijam20242321Keywords:
Dengue, Febrile, Thrombocytopenia, HIV, InfectionAbstract
Dengue is tropic infectious disease which concentrated in tropical and subtropical regions. Human immunodeficiency virus (HIV) is an infection that attacks the body’s immune system. A 29-year-old female admitted to hospital with history of febrile thrombocytopenia with HIV infection on highly active anti-retroviral therapy (HAART). First, the patient was assessed with dengue hemorrhagic fever, but anti-dengue immunoglobulin G (IgG) and IgM were negative. Febrile thrombocytopenia occurs not only in dengue, but also in other conditions. Person with HIV experience a wide range of hematological abnormalities, the most prevalent of which are cytopenias, which can be anemia, leukopenia, thrombocytopenia, or a combination of these. Fever and thrombocytopenia are closely related to dengue infection, but this condition can also be caused by various factors.
References
Khetarpal N, Khanna I. Dengue fever: causes, complications, and vaccine strategies. J Immunol Res. 2016;1-14.
Gubler DJ. Dengue and Dengue hemorrhagic fever. Clin Microbiol Rev. 1998;11.
Wang WH, Urbina AN, Chang MR, Assavalapsakul W, Lu PL, Chen YH, et al. Dengue hemorrhagic fever-A systemic literature review of current perspectives on pathogenesis, prevention and control. J Microbiol Immunol Infect. 2020;53(6):963-78.
Htun TP, Xiong Z, Pang J. Clinical signs and symptoms associated with WHO severe dengue classification: a systematic review and meta-analysis. Emerg Microbes Infect. 2021;10(1):1116-28.
HIV-Global. Cited 2024. Available at. https://www.who.int/health-topics/hiv-aids. Accessed on 12th March 2024.
Deeks SG, Overbaugh J, Phillips A, Buchbinder S. HIV infection. Nat Rev Dis Primer. 2015;1(1):15035.
Boniphace I. HIV/AIDS clinical manifestations and their implication for patient clinical staging in resource limited settings in Tanzania. Open AIDS J. 2011;5(1):9-16.
Nascimento FG, Tanaka PY. Thrombocytopenia in HIV-Infected Patients. Indian J Hematol Blood Transfus. 2012;28(2):109-11.
Dengue virus infection: Clinical manifestations and diagnosis. cited 2024. Available at. https://medilib.ir.
Ng DH, Wong JG, Thein TL, Leo YS, Lye DC. The Significance of Prolonged and Saddleback Fever in Hospitalised Adult Dengue. PLoS ONE. 2016;11(12):167025.
Obeagu E, Nwosu D. Adverse drug reactions in HIV/AIDS patients on highly active antiretro viral therapy: a review of prevalence. 2019;6:45–8.
Opie J, Verburgh E, Bailly J, Mayne E, Louw V. Hematological complications of Human Immunodeficiency Virus (HIV) Infection: An Update From an HIV-Endemic Setting. Open Forum Infect Dis. 2024;11(4):162.
Getawa S, Aynalem M, Bayleyegn B, Adane T. The global prevalence of thrombocytopenia among HIV-infected adults: A systematic review and meta-analysis. Int J Infect Dis. 2021;105:495–504.
Shen Y, Wang J, Wang Z, Shen J, Qi T, Song W, et al. A cross-sectional study of leukopenia and thrombocytopenia among Chinese adults with newly diagnosed HIV/AIDS. Biosci Trends. 2015;9(2):91-6.
Raadsen M, Du Toit J, Langerak T, Van Bussel B, Van Gorp E, Goeijenbier M. Thrombocytopenia in Virus Infections. J Clin Med. 2021;10(4):8.