Study of factors affecting sarcopenia in PLHIV
DOI:
https://doi.org/10.18203/2349-3933.ijam20243811Keywords:
Sarcopenia, PLHIV, Risk factors, HAARTAbstract
Background: This study aims to determine the frequency of sarcopenia in PLHIV and determine the factors affecting sarcopenia in PLHIV.
Methods: The patients fulfilling the inclusion criteria were enrolled for the study after obtaining informed consent. Case record form was used to record relevant history. SARC-F (sluggishness, assistance in walking, rising from a chair, climbing stairs, falls) score is recorded by questionnaire. Hand grip strength and skeletal muscle mass index (SMI) were recorded. The correlation between grip strength and SMI with the duration of treatment in different regimens of HAART in PLHIV were studied. Possible factors affecting sarcopenia were determined based on history taken. All the parameters were compared between patients with and without sarcopenia. P value <0.05 was considered statistically significant. R version 4.1.2 statistical software was used for the statistical analysis.
Results: Sarcopenia was more commonly found in middle aged participants, who were less adherent to therapy, had a past history of tuberculosis, consumed alcohol, followed a vegetarian diet and did not exercise regularly.
Conclusion: Sarcopenia is more common in middle-aged individuals with long-term AIDS, especially those on prolonged ART. It’s linked to non-adherence to ART, alcohol consumption, history of tuberculosis, and reduced physical activity. Strict adherence to ART, avoiding alcohol, increasing protein intake, and exercising regularly helps to combat this.
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References
Fauci A, Folkers G, Lane H. Harrison's principles of internal medicine. 20th ed. New Delhi. McGraw Hill Education. 2018; 1402.
Global HIV & AIDS statistics-s2020 fact sheet. 2020. Available at: https://www.unaids.org. Accessed on 17 August 2024.
India HIV Estimates: Report. National Aids Control Organisation. 2019. Available from: http://naco.gov.in. Accessed on 23 August 2024.
Harrison KM, Song R, Zhang X. Life expectancy after HIV diagnosis based on national HIV surveillance data from 25 states, United States. J Acquir Immune Defic Syndr. 2010;53(1):124-30.
Cruz-Jentoft AJ, Bahat G, Bauer J, Boirie Y, Bruyère O, Cederholm T, et al. Sarcopenia: revised European consensus on definition and diagnosis. Age Ageing. 2019 01 1;48(1):16-31.
Arnaudo E, Dalakas M, Shanske S, Moraes CT, DiMauro S, Schon EA. Depletion of muscle mitochondrial DNA in AIDS patients with zidovudine-induced myopathy. Lancet. 1991;337(8740):508-10.
US centers for disease control and prevention. pneumocystis pneumonia-Los Angeles. Los Angeles: morbidity and mortality weekly Report. 1981. Available at: https://www.cdc.gov/mmwr/preview. Accessed on 24 August 2024.
Fauci A, Folkers G, Lane H. Harrison's principles of internal medicine. 20th ed. New York: McGraw Hill Education; 2015; 1393.
Chandra N, Deshpande A. API textbook of Medicine. 11th ed. The Association of Physicians of India. 2019; 349.
A Timeline of HIV and AIDS. HIV. 2019. Available at: https://www.hiv.gov/hiv-basics. Accessed on 28 August 2024.
Sepkowitz K. AIDS: The first 20 years. New England J Med. 2001;344(23):1764-72.
Clumeck N, Mascart-Lemone F, De Maubeuge J, Brenez D, Marcelis L. Acquired immune deficiency syndrome in black Africans. The Lancet. 1983;321(8325):642.
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