Analysis of positive predictors in diagnosing lung cancer on transthoracic and transbronchial procedure

Desy Irene Tandibua; Ni Wayan Candrawati; Ida Ayu Jasminarti Dwi Kusumawardani; I. Gede Ketut Sajinadiyasa; Ni Luh Putu Eka Arisanti; I. Desak Putu Agung Krisdanti

doi:10.18203/2349-3933.ijam20243442

Authors

Desy Irene Tandibua Department of Pulmonology and Respiratory Medicine, Prof. I.G.N.G. Ngoerah General Hospital, Faculty of Medicine, Udayana University, Bali, Indonesia
Ni Wayan Candrawati Department of Pulmonology and Respiratory Medicine, Prof. I.G.N.G. Ngoerah General Hospital, Faculty of Medicine, Udayana University, Bali, Indonesia
Ida Ayu Jasminarti Dwi Kusumawardani Department of Pulmonology and Respiratory Medicine, Prof. I.G.N.G. Ngoerah General Hospital, Faculty of Medicine, Udayana University, Bali, Indonesia
I. Gede Ketut Sajinadiyasa Department of Pulmonology and Respiratory Medicine, Prof. I.G.N.G. Ngoerah General Hospital, Faculty of Medicine, Udayana University, Bali, Indonesia
Ni Luh Putu Eka Arisanti Department of Pulmonology and Respiratory Medicine, Prof. I.G.N.G. Ngoerah General Hospital, Faculty of Medicine, Udayana University, Bali, Indonesia
I. Desak Putu Agung Krisdanti Department of Pulmonology and Respiratory Medicine, Prof. I.G.N.G. Ngoerah General Hospital, Faculty of Medicine, Udayana University, Bali, Indonesia

DOI:

https://doi.org/10.18203/2349-3933.ijam20243442

Keywords:

Clinical symptoms, Breathlessness, Cough, Hemoptyisis, Chest pain, Transthoracic, Positivity, Lung cancer

Abstract

Background: Lung cancer remains the most cause of death due to cancer. Due to high mortality rate of lung cancer, early diagnosis of lung cancer plays a very important role in therapeutic management. Clinical symptoms and tumor characteristics such as size and location are found to vary in lung cancer patients. Various modalities can be used to obtain materials or samples include transthoracic and transbronchial methods. Research was conducted to analyze positive predictors of cancer between transthoracic and transbronchial procedures in lung cancer patients.

Methods: This research is an analytical observational study with a cross-sectional design in using secondary data through medical records from January 2022 to December 2023. Univariate analysis presents data in the form of frequency, mean and standard deviation. Bivariate analysis was carried out using chi-square and multivariate analysis using multiple logistic regression. The measure used as a predictor is the adjusted odds ratio. Inference or conclusion is based on the 95% confident interval and p value at the alpha value limit of 0.05. The entire data process above uses SPSS 26.0 statistical software

Results: The total research subjects who met the research requirements were 111 patients. The characteristics of the research subjects were symptoms of cough (n=97; 87.4%), hemoptyisis (n=51; 45.9%), breathlessness (n=104; 93.7%) and chest pain (n=87; 78.4%), mostly peripheral tumor (n=70; 63.1%) and size >3 cm (n=103; 92.8%). Logistic regression analysis showed cough symptoms and peripheral tumor location each had an adjOR value of 5.247 (95% CI 1.432-19.552; p=0.013) and adjOR 0.088 (95% CI 0.034-0.229; p=0.000) for lung cancer positivity on transbronchial procedure. On transthoracic procedure, cough symptoms and peripheral tumor location respectively had an adjOR value of 0.190 (95% CI 0.051-0.703; p=0.013) and adjOR 11.407 (95% CI 4.374-29.747; p=0.000) for lung cancer positivity.

Conclusions: Cough is a positive predictor of lung cancer in transbronchial procedures. Meanwhile, peripheral tumor location is a positive predictor of lung cancer in transthoracic procedures.

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