Heme iron polypeptide in treating iron deficiency anemia among patients with inflammatory bowel disease, chronic liver disease, and gastrointestinal bleeding: a case series
DOI:
https://doi.org/10.18203/2349-3933.ijam20250377Keywords:
Iron deficiency anemia, Heme iron polypeptide, Chronic liver disease, Cirrhosis, Inflammatory bowel disease, Occult gastrointestinal bleed, Fe dailyAbstract
Iron deficiency anemia commonly complicates gastrointestinal and hepatic disorders, with standard oral iron therapies often limited by poor tolerability and gastrointestinal side effects. Heme Iron Polypeptide (HIP) offers a potential alternative, providing effective, well-tolerated iron supplementation. In three cases presented, HIP improved hemoglobin levels without adverse events, underscoring its promise as a viable therapeutic option in patients with gastrointestinal and hepatic disorders with iron deficiency anemia who are intolerant to conventional iron therapies.
Metrics
References
Nsaful KO, Paintsil AB, Dakubo JC, Nsaful J, Appiah-Labi K, Nartey E. An evaluation of bacterial infection of split thickness skin grafts: At the Korle Bu Teaching Hospital. World J Gastroenterol. 2021;22(35):7908–25.
Kaitha S, Bashir M, Ali T. Iron deficiency anemia in inflammatory bowel disease. World J Gastroint Pathophysiol. 2015;6(3):62–72. DOI: https://doi.org/10.4291/wjgp.v6.i3.62
Manrai M, Dawra S, Kapoor R, Srivastava S, Singh A. Anemia in cirrhosis: An underestimated entity. World J Clin Cases. 2022;10(3):777–89. DOI: https://doi.org/10.12998/wjcc.v10.i3.777
Cotter J, Baldaia C, Ferreira M, Macedo G, Pedroto I. Diagnosis and treatment of iron-deficiency anemia in gastrointestinal bleeding: A systematic review. World J of Gastroenterol. 2020;26(45):7242–57. DOI: https://doi.org/10.3748/wjg.v26.i45.7242
GBD. Anaemia Collaborators. Prevalence, years lived with disability, and trends in anaemia burden by severity and cause, 1990-2021: findings from the Global Burden of Disease Study 2021. The Lancet. Haematol. 2021;10(9):713-34.
Tomasević R, Gluvić Z, Mijač D, Sokić-Milutinović A, Lukić S, Milosavljević T. Anemia as a problem: GEH approach. Digestive Diseases (Basel, Switzerland). 2022;40(2):133–41. DOI: https://doi.org/10.1159/000516480
Hébert PC, Wells G, Blajchman MA, Marshall J, Martin C, Pagliarello G, et al. A multicenter, randomized, controlled clinical trial of transfusion requirements in critical care. The New England J of Med. 1999;340(6):409–17. DOI: https://doi.org/10.1056/NEJM199902113400601
Bayraktar UD. Treatment of iron deficiency anemia associated with gastrointestinal tract diseases. WJG. 2010;16(22):2720. DOI: https://doi.org/10.3748/wjg.v16.i22.2720
Tansukkasem S, Kaewpathomsri P, Jonjaroen V, Payongsri P, Lertsiri S, Niamsiri N. Production and characterization of heme iron polypeptide from the blood of skipjack tuna (Katsuwonus pelamis) using enzymatic hydrolysis for food supplement application. Foods (Basel, Switzerland). 2022;12(17):3249. DOI: https://doi.org/10.3390/foods12173249
Young MF, Griffin I, Pressman E, McIntyre AW, Cooper E, McNanley T, et al. Utilization of iron from an animal-based iron source is greater than that of ferrous sulfate in pregnant and nonpregnant women. J Nutr. 2010;140(12):2162–6. DOI: https://doi.org/10.3945/jn.110.127209
Nissenson AR, Charytan C. Controversies in iron management. Kidney Int Suppl. 2003;(87):64-71. DOI: https://doi.org/10.1046/j.1523-1755.64.s87.10.x
Nagaraju SP, Cohn A, Akbari A, Davis JL, & Zimmerman DL. Heme iron polypeptide for the treatment of iron deficiency anemia in non-dialysis chronic kidney disease patients: a randomized controlled trial. BMC Nephrol. 2013;14:64. DOI: https://doi.org/10.1186/1471-2369-14-64
Seligman, P. A., Moore, G. M., & Schleicher, R. B. (2000). Clinical studies of hip: An oral heme-iron product. Nutrition Research (New York). 2000;20(9):1279–86. DOI: https://doi.org/10.1016/S0271-5317(00)00215-3
Agrawal DS. Obstetrics and Gynaecology Department, SSG Hospital, Vadodara, Gujarat- 390001, India, Alevoor, D. S., & Postgraduate in Obstetrics and Gynaecology Department, SSG Hospital, Vadodara, Gujarat- 390001, India. Heme iron polypeptide in treatment of anemia in pregnancy. Obsgy Review. J of Obstetric and Gynecol. 2018;4(3):55–61. DOI: https://doi.org/10.17511/joog.2018.i03.03
Pal B, Deshpande H, Sundari T, Biniwale P, Shah K, Goel S, et al. Heme iron polypeptide in iron deficiency anemia of pregnancy: Current evidence. Open J Obst and Gynecol. 2017;7(4):420–31. DOI: https://doi.org/10.4236/ojog.2017.74044
Downloads
Published
How to Cite
Issue
Section
