Patients with acute liver failure due to hepatitis B: a case report
DOI:
https://doi.org/10.18203/2349-3933.ijam20251080Keywords:
Hepatitis B, Acute liver failure, JaundiceAbstract
Hepatitis B is an infectious disease of liver cells by the hepatitis B virus (HBV). Hepatitis B is characterized by symptoms such as jaundice, decreased appetite, and abdominal pain. Acute liver failure (ALF) is one of the serious complications of hepatitis B. Previous studies reported that the incidence of acute hepatitis B patients reached 41.7% within 28 days after hospitalization, with high mortality rates on the 28th and 90th days, namely 43.9% and 70.4%. In these patients, they showed classic symptoms of persistent jaundice, nausea, vomiting, pain in the right upper quadrant, and progressive bloating. Extreme elevations in bilirubin and liver enzymes indicate a high level of hepatocyte necrosis, which is common in ALF due to acute HBV infection or reactivation of chronic infection. Patients with a history of hepatitis B develop ALF. ALF due to hepatitis B infection is a serious condition that requires immediate medical attention. Early diagnosis, including identification of classic symptoms such as jaundice, nausea, and abdominal pain, is essential. Management should include combination antiviral and supportive therapy to prevent further complications, including death. With better knowledge and understanding of the disease mechanism and clinical management, it is hoped that the prognosis of patients with this condition can improve in the future.
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Huang DQ, Lim SG. Life After s Loss: Impact of Hepatitis B Antigen Loss on Future Patient Outcomes. Clin Liver Dis. 2020;16(6):262-5. DOI: https://doi.org/10.1002/cld.983
Pertiwi MD. Distribusi Kejadian Hepatitis B Menurut Cakupan Imunisasi HB-0 dan Cakupan K4 di Jawa Timur. IKESMA. 2020;16(1):36. DOI: https://doi.org/10.19184/ikesma.v16i1.15673
Ellis K, Brandt-Sarif M, Sunny J, Koyfman S. General Hepatitis. Pediatr Rev. 2022;43(9):493-506. DOI: https://doi.org/10.1542/pir.2021-005279
Guan X, Xing F, Li Y. Alcohol consumption increases the incidence of hepatocellular carcinoma in patients with hepatitis B cirrhosis but not in patients with hepatitis C cirrhosis. Eur J Gastroenterol Hepatol. 2020;33(9):1218-21. DOI: https://doi.org/10.1097/MEG.0000000000001837
Sunkara PR, Weise K, Jafri SM. S3626 Acute Liver Failure Due to Discontinuation of Hepatitis B Virus (HBV) Therapy. Am J Gastroenterol. 2023;118(10S):S2355-6. DOI: https://doi.org/10.14309/01.ajg.0000964144.85689.70
Ledoux N. Hepatitis B and Acute Liver Failure. Crit Care Nurs Clin North Am. 2022;34(3):259-265. DOI: https://doi.org/10.1016/j.cnc.2022.04.012
Tang X, Qi T, Li B, Chen J. Pre-acute-on-chronic liver failure in hepatitis B-related patients. J Hepatol. 2021;74(2):479-80. DOI: https://doi.org/10.1016/j.jhep.2020.09.001
Samo AA, Laghari ZA, Baig NM, Khoso GM. Prevalence and Risk Factors Associated with Hepatitis B and C in Nawabshah, Sindh, Pakistan. Am J Trop Med Hyg. 2020;104(3):1101-5. DOI: https://doi.org/10.4269/ajtmh.20-1228
Hamed D, Eidi A, Keshtkaran Z, Shahedi A, Soufi O, Rezaei B, et al. Changing the Epidemiology and Pattern of Hepatitis B and C in the South of Fars Province, Southern Iran: 2015-2021. Jundishapur J Chronic Dis Care. 2023;12(3):e137658. DOI: https://doi.org/10.5812/jjcdc-137658
Liu Y, Wu D, Zhang K, Ren R, Liu Y, Zhang S, et al. Detection technology and clinical applications of serum viral products of hepatitis B virus infection. Front Cellular Infect Microbiol. 2024;14:1402001. DOI: https://doi.org/10.3389/fcimb.2024.1402001
Shi YW, Yang RX, Fan JG. Chronic hepatitis B infection with concomitant hepatic steatosis: Current evidence and opinion. World J Gastroenterol. 2021;27(26):3971-83. DOI: https://doi.org/10.3748/wjg.v27.i26.3971
Hsu PY, Hsu CT, Yeh ML, Huang CF, Huang CI, Liang PC, et al. Early Fibrosis but Late Tumor Stage and Worse Outcomes in Hepatocellular Carcinoma Patients Without Hepatitis B or Hepatitis C. Digestive Dis Sci. 2019;65(7):2120-9. DOI: https://doi.org/10.1007/s10620-019-05938-3
Zhang Q, Peng H, Liu X, Wang H, Du J, Luo X, et al. Chronic Hepatitis B Infection with Low Level Viremia Correlates with the Progression of the Liver Disease. J Clin Translational Hepatol. 2021;9(6):850-9. DOI: https://doi.org/10.14218/JCTH.2021.00046
Mak LY, Rex WHH, Fung J, Liu F, Danny KHW, Cheung KS, et al. Diverse effects of hepatic steatosis on fibrosis progression and functional cure in virologically quiescent chronic hepatitis B. J Hepatol. 2020;73(4):800-6. DOI: https://doi.org/10.1016/j.jhep.2020.05.040
Liu GZ, Xu XW, Tao SH, Gao MJ, Hou ZH. HBx facilitates ferroptosis in acute liver failure via EZH2 mediated SLC7A11 suppression. J Biomed Sci. 2021;28(1):67. DOI: https://doi.org/10.1186/s12929-021-00762-2
Biswas S, Kumar R, Subrat Kumar Acharya, Makharia GK. Prognostic Scores in Acute Liver Failure Due to Viral Hepatitis. Diagnostics. 2023;13(6):1035-5. DOI: https://doi.org/10.3390/diagnostics13061035
Manea M, Ion Mărunțelu, Constantinescu I. A New Assessment of Two Transferase-Based Liver Enzymes in Low-and High-Fibrosis Patients Chronically Infected with Hepatitis B Virus: A Meta-Analysis and Pilot Study. J Clin Med. 2024;13(13):3903-3. DOI: https://doi.org/10.3390/jcm13133903
Wang L, Xu W, Li X, Chen D, Zhang Y, Chen Y, et al. Long-term prognosis of patients with hepatitis B virus-related acute-on-chronic liver failure: a retrospective study. BMC Gastroenterol. 2022;22(1):162. DOI: https://doi.org/10.1186/s12876-022-02239-4
Kandel P, McDonald P, Ghassan Bachuwa. S3514 Acute Liver Failure Due to Acute Hepatitis B Infection. Am J Gastroenterol. 2020;115(1):S6-6. DOI: https://doi.org/10.14309/01.ajg.0000716104.05630.45
Alexandra S, Mukhtar NA, Jamile Wakim-Fleming, Alqahtani SA, Wong RJ, Limketkai BN, et al. Acute Liver Failure Guidelines. Am J Gastroenterol. 2023;118(7):1128-53. DOI: https://doi.org/10.14309/ajg.0000000000002340
Arfianti A, Sabillah Sumpena A, Andrini Djojosugito F, Kartika Sari D, Julia Paulina A. Genotype Distribution of Vitamin D Receptor Polymorphisms among Indonesian Patients with Chronic Hepatitis B. Rep Biochemist Molec Biol. 2021;9(4):463-9. DOI: https://doi.org/10.52547/rbmb.9.4.463
Gunardi H, Iskandar MY, Turyadi null, Ie SI, Dwipoerwantoro PG, Gani RA, et al. Hepatitis B virus infection in children of HBV-related chronic liver disease patients: a study of intra-familial HBV transmission. Hepatol Int. 2017;11(1):96-104. DOI: https://doi.org/10.1007/s12072-016-9764-z
Wahyuni, Charlton MR, Mohamed R, Jose Decena Sollano, Kyaw Soe Tun, Thi T, et al. Asian consensus recommendations on optimizing the diagnosis and initiation of treatment of hepatitis B virus infection in resource‐limited settings. J Viral Hepatitis. 2019;27(5):466-75. DOI: https://doi.org/10.1111/jvh.13244
Pompili E, Iannone G, Carrello D, Giacomo Z, Baldassarre M, Paolo C. Managing multiorgan failure in Acute on chronic liver failure (ACLF). Seminars in Liver Disease. 2024;44(4):492-509. DOI: https://doi.org/10.1055/a-2448-0664
Li F, Zhang Y, Wang ZH, Gao S, Fan YC, Wang K. SOCS1 methylation level is associated with prognosis in patients with acute-on-chronic hepatitis B liver failure. Clin Epigenetics. 2023;15(1):79. DOI: https://doi.org/10.1186/s13148-023-01495-9
Jia L, Xue R, Zhu Y, Zhao J, Li J, He WP, et al. The efficacy and safety of methylprednisolone in hepatitis B virus-related acute-on-chronic liver failure: a prospective multi-center clinical trial. BMC Med. 2020;18(1):383. DOI: https://doi.org/10.1186/s12916-020-01814-4
Olsen M, Oakes K, Bowyer T, Cargill Z, Mizzi O, Gray C, et al. O10 Emergency department (ED) opt out BBV testing: an effective tool to diagnose the undiagnosed. 2024;A7:1-7. DOI: https://doi.org/10.1136/gutjnl-2024-BASL.8
Rowe IA, Chauhan A, Armstrong MJ, Allison MED, Webb G, Pirani T, et al. Liver transplantation for critically ill patients with acute on chronic liver failure: a prospective national programme of waitlist prioritisation. Lancet Regional Heal Eur. 2024;101067-7. DOI: https://doi.org/10.1016/j.lanepe.2024.101067
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