Interstitial lung disease as initial presentation of ANCA associated vasculitis
DOI:
https://doi.org/10.18203/2349-3933.ijam20251944Keywords:
Acute kidney injury, Antineutrophil cytoplasmic antibody, Associated vasculitis, ANCA associated vasculitis, Interstitial lung disease, MPO-ANCA, Pulmonary fibrosisAbstract
Interstitial lung disease (ILD) can occur in relation to many autoimmune processes. Occasionally, ILD may also occur in the presence of anti-neutrophil cytoplasmic antibodies (ANCA). In this paper, we report the case of a 60-year-old female with a long-standing history of ILD who later developed anti-neutrophil cytoplasmic antibody (ANCA)-associated vasculitis (AAV) and glomerulonephritis. Her clinical progression, where ILD emerged prior to systemic manifestations of AAV, supports the hypothesis that rarely ILD may be an early manifestation of ANCA-associated vasculitis. Additionally, we reviewed existing literature examining the connection between ILD and AAV. The published data suggest that ILD may precede ANCA-associated vasculitis, reinforcing the importance of a multidisciplinary approach for optimal management. Further research is necessary to further understand the underlying mechanisms linking ILD and AAV and to develop evidence-based treatment guidelines.
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