A case report: Cleistanthus collinus (Oduvan) poisoning

Authors

  • Jimmy Joseph Department of Internal Medicine, Aster DM Healthcare, Dubai, UAE
  • Renoy A. Henry Department of Internal Medicine, Amrita Institute of Medical Sciences, Kerala, India

DOI:

https://doi.org/10.18203/2349-3933.ijam20252535

Keywords:

Cleistanthus collinus, Respiratory failure, Renal tubular acidosis, Hypokalemia, Arrhythmia

Abstract

Cleistanthus collinus-an extremely toxic plant has been reported to be used for deliberate self-harm in different parts of the country, notably South India. Toxins contained include Cleistanthin A and B arediphyllin derivatives and are known to cause neuromuscular blockade, type 2 respiratory failure, type 2 renal tubular acidosis, hypokalaemia, cardiac arrhythmias. We are presenting a case report where the poisoning was associated with type 2 respiratory failure, acute kidney injury, type 2 renal tubular acidosis, hypokalaemia, acute respiratory distress syndrome. The patient was managed with intravenous N-acetylcysteine, ventilatory support and multiple sessions of dialysis following which the patient after a prolonged stay of 29 days was discharged from the hospital.

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References

Gorton HC, Webb RT, Kapur N, Ashcroft DM. Non-psychotropic medication and risk of suicide or attempted suicide: a systematic review. BMJ Open. 2016;6(1):9074. DOI: https://doi.org/10.1136/bmjopen-2015-009074

Eddleston M. Patterns and problems of deliberate self‐poisoning in the developing world. QJM. 2000;93(11):715-31. DOI: https://doi.org/10.1093/qjmed/93.11.715

Bose A, Sandal SC, Suganthy P, Raghava V, Alex R, Muliyil J, et al. Self-harm and self-poisoning in southern India: Choice of poisoning agents and treatment. Trop Med Int Health. 2009;14:761–5. DOI: https://doi.org/10.1111/j.1365-3156.2009.02293.x

Joseph A, Abraham S, Muliyil JP, George K, Prasad J, Minz S, et al. Evaluation of suicide rates in rural India using verbal autopsies, 1994-1999. BMJ. 2003;326:1121–2. DOI: https://doi.org/10.1136/bmj.326.7399.1121

Aaron R, Joseph A, Abraham A, Muliyil J, George K, Prasad J, et al. Suicides in young people in rural southern India. Lancet. 2004;363:1117–8. DOI: https://doi.org/10.1016/S0140-6736(04)15896-0

Eddleston M, Ariaratnam CA, Meyer WP, Perera G, Kularatne AM, Attapattu S, et al. Epidemic of self-poisoning with seeds of the yellow oleander tree (Thevetia Peruviana) in northern Sri Lanka. Trop Med Int Health. 1999;4:266–73. DOI: https://doi.org/10.1046/j.1365-3156.1999.00397.x

Eddleston M, Juszczak E, Buckley NA, Senarathna L, Mohamed F, Dissanayake W, et al. Multiple-dose activated charcoal in acute self-poisoning: A randomised controlled trial. Lancet. 2008;371:579–87. DOI: https://doi.org/10.1016/S0140-6736(08)60270-6

Aleem MA, Paramasivam M. Spectrum of acute poisoning in villagers. J Assoc Physicians India. 1993;43:859.

Batra AK, Keoliya AN, Jadhav GU. Poisoning: An unnatural cause of morbidity and mortality in rural India. J Assoc Physicians India. 2003;51:955–9.

Devaprabhu S, Manikumar S, David SS. Toxico-epidemiology and prognostic profile of patients with Cleistanthus collinus poisoning. Indian J Trauma Anaesth Crit Care. 2007;8:642–6.

Ramesh C, Ravindranath N, Ram TS, Das B. Arylnaphthalide lignans from Cleistanthus collinus. Chem Pharm Bull. 2003;51:1299–300. DOI: https://doi.org/10.1248/cpb.51.1299

Rajagopal Naidu S, Venkat Rao P, Subrahmanyam CA. The microscopy and chemistry of oduvin. J Proc Inst Chem India. 1944;16:59–63.

Nampoothiri K, Chrispal A, Begum A, Jasmine S, Gopinath KG, Zachariah A. A clinical study of renal tubular dysfunction in Cleistanthus collinus (Oduvanthalai) poisoning. Clin Toxicol (Phila) 2010;48:193–7. DOI: https://doi.org/10.3109/15563651003641786

Thomas K, Dayal AK, Gijsbers A, Seshadri MS. Oduvanthalai leaf poisoning. J Assoc Physicians India. 1987;35:769–71.

1Eswarappa S, Chakraborty AR, Palatty BU, Vasnaik M. Cleistanthus collinus poisoning: Case reports and review of literature. J Toxicol Clin Toxicol. 2003;41:369–72. DOI: https://doi.org/10.1081/CLT-120022005

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Published

2025-08-21

How to Cite

Joseph, J., & Henry, R. A. (2025). A case report: Cleistanthus collinus (Oduvan) poisoning. International Journal of Advances in Medicine, 12(5), 491–493. https://doi.org/10.18203/2349-3933.ijam20252535