Preconception counseling in women with pre-existing diabetes mellitus: evidence-based strategies to improve pregnancy outcomes
DOI:
https://doi.org/10.18203/2349-3933.ijam20261889Keywords:
Preconception counseling, Pregestational diabetes, Glycemic control, Pregnancy outcomes, Maternal complications, Fetal complicationsAbstract
Pregnancy complicated by pre-existing diabetes mellitus is associated with increased maternal and fetal morbidity. Hyperglycemia during the periconceptional period significantly increases the risk of congenital malformations, spontaneous abortions, and adverse perinatal outcomes. Preconception counseling plays a vital role in optimizing metabolic control and minimizing complications before pregnancy occurs. The aim of this review is to summarize current evidence and highlight practical clinical strategies for optimizing pregnancy outcomes in women with pre-existing diabetes. A literature search was conducted using PubMed and Google Scholar for articles published between 2000 and 2024 using keywords “preconception care,” “diabetes,” and “pregnancy outcomes”. Relevant literature was identified from international clinical guidelines and peer-reviewed publications using standard database searches. Optimal preconception care includes achieving strict glycemic control, screening for diabetic complications, reviewing medications, initiating folic acid supplementation, optimizing body weight, and ensuring effective contraception until glycemic targets are achieved. Multidisciplinary care involving obstetricians, endocrinologists, dieticians, and ophthalmologists is essential for comprehensive management. Evidence suggests that structured preconception programs significantly reduce congenital malformations, perinatal mortality, and maternal complications in diabetic pregnancies. Despite this, many pregnancies in women with diabetes remain unplanned, emphasizing the need for improved counseling and awareness. Early identification and management of reproductive-age women with diabetes should be incorporated into routine clinical care. Implementation of standardized preconception counseling protocols can substantially improve maternal and fetal outcomes.
References
Feig DS, Hwee J, Shah BR, Giliian LB, Arlene SB, Lorraine LL, et al. Trends in incidence of diabetes in pregnancy and serious perinatal outcomes. Lancet Diabetes Endocrinol. 2014;2(6):108-14.
Kitzmiller JL, Block JM, Brown FM, Patrick MC, Deborah LC, Donald RC, et al. Managing preexisting diabetes for pregnancy. Diabetes Care. 2008;31(5):1060-79.
American Diabetes Association. Management of diabetes in pregnancy: Standards of Care in Diabetes-2023. Diabetes Care. 2023;46(1):S254-66.
National Institute for Health and Care Excellence. Diabetes in pregnancy: management from preconception to the postnatal period. NICE guideline NG3. London: NICE. 2020.
Mills JL. Malformations in infants of diabetic mothers. Birth Defects Res A. 2010;88:769-78.
Correa A, Gilboa SM, Besser LM, Lorenzo DB, Cynthia AM, Charlotte AH, et al. Diabetes mellitus and birth defects. Am J Obstet Gynecol. 2008;199(3):237.e1-9.
Jensen DM, Damm P, Moelsted-Pedersen L, Per O, Jes GW, Margrethe M, et al. Outcomes in type 1 diabetic pregnancies: influence of glycemic control. Diabetes Care. 2004;27(12):2819-23.
Temple R, Aldridge V, Greenwood R, Philip H, Michael S, Katharine S. Association between first-trimester HbA1c and adverse pregnancy outcomes in diabetic women. BMJ. 2002;325(7375):1275-6.
Nielsen GL, Møller M, Sørensen HT. HbA1c levels and risk of congenital malformations. BMJ. 2001;322:156-8.
Dunne FP, Avalos G, Durkan M, Mitchell Y, Gallacher T, Keenan M, et al. Pregnancy outcomes in women with type 2 diabetes. Diabet Med. 2003;20(5):24-8.
Balsells M, García-Patterson A, Corcoy R. Systematic review of outcomes in women with type 2 diabetes in pregnancy. Diabetologia. 2009;52:102-9.
Persson M, Norman M, Hanson U. Obstetric and perinatal outcomes in type 1 diabetic pregnancies. Diabetes Care. 2009;32:2005-9.
Evers IM, de Valk HW, Visser GH. Risk of complications of pregnancy in women with type 1 diabetes: nationwide prospective study. BMJ. 2004;328:915.
McCance DR. Pregnancy and diabetes. Best Pract Res Clin Endocrinol Metab. 2011;25:945-58.
Lapolla A, Dalfrà MG, Fedele D. Pregnancy complicated by diabetes: an emerging problem. Diabetes Res Clin Pract. 2008;80:2-7.
Wahabi HA, Alzeidan RA, Bawazeer GA, Lubna AA, Samia AE. Preconception care for diabetic women for improving maternal and fetal outcomes. Cochrane Database Syst Rev. 2015;8:CD007776.
Murphy HR, Roland JM, Skinner TC, David S, Eleanor G, Nicholas JM, et al. Effectiveness of preconception care in diabetic women: population-based cohort study. Diabetologia. 2010;53:2217-24.
Ray JG, O’Brien TE, Chan WS. Preconception care and risk of congenital anomalies in women with diabetes mellitus. QJM. 2001;94:435-44.
World Health Organization. WHO recommendations on antenatal care for a positive pregnancy experience. Geneva: WHO; 2016. Available from: https://www.who.int/publications/i/item/WHO-RHR-18.02. Accessed on 12 April 2026.
Hawthorne G. Maternal complications in diabetic pregnancy. Best Pract Res Clin Obstet Gynaecol. 2011;25:77-90.
Feig DS, Donovan LE, Corcoy R, Murphy KE, Amiel SA, Hunt KF, et al. Continuous glucose monitoring in pregnant women with type 1 diabetes (CONCEPTT): a multicentre international randomised controlled trial. Lancet. 2017;390(10110):2347-59.
Mackillop L, Hirst JE, Bartlett KJ, Birks JS, Clifton L, Farmer AJ, et al. Comparing the efficacy of a mobile phone-based blood glucose management system with standard clinic care in women with gestational diabetes: randomized controlled trial. JMIR Mhealth Uhealth. 2018;6(3):e71.