Physician perspectives on spacer device usage, prescription patterns, and clinical decision-making factors in the management of respiratory conditions: a nationwide, multicenter cross-sectional observational study

Authors

  • Prachi Jain Medical Affairs Division, Alkem Laboratories Ltd Mumbai, Maharashtra, India
  • Ajitkumar Gondane Medical Affairs Division, Alkem Laboratories Ltd Mumbai, Maharashtra, India
  • Dattatray Pawar Medical Affairs Division, Alkem Laboratories Ltd Mumbai, Maharashtra, India
  • Akhilesh Sharma Medical Division, Alkem Laboratories Ltd Mumbai, Maharashtra, India

DOI:

https://doi.org/10.18203/2349-3933.ijam20262324

Keywords:

Asthma, Valved holding chamber, Inhaler technique, Aerosol therapy

Abstract

Background: Pressurized metered-dose inhalers (pMDIs) are widely used for delivering bronchodilators and corticosteroids; however, their effectiveness is often compromised by poor inhalation techniques, leading to inadequate drug deposition in the lungs and suboptimal disease control. Spacer devices, including valved holding chambers (VHCs), are designed to overcome these challenges by improving aerosol delivery, reducing oropharyngeal deposition, and enhancing treatment adherence in patients with respiratory conditions. This survey aimed to assess physicians’ perspectives on the usage, prescription patterns, and decision-making factors associated with spacer devices in respiratory conditions.

Methods: A cross-sectional survey was conducted among qualified medical practitioners using a structured questionnaire. Data on demographics, indications, and perceptions regarding spacer use were collected from 6,787 respondents.

Results: Chest physicians constituted the largest respondent group (n=3,261). Nearly 80% of clinicians reported frequently or occasionally recommending spacer devices. Spacer use was most commonly associated with asthma maintenance therapy (n=5,214), acute asthma (n=3,861), and chronic obstructive pulmonary disease (COPD) (n=4,460). Key factors influencing prescription included disease severity, patient age, and the patient’s ability to use inhalers correctly. Major barriers identified were lack of patient/caregiver awareness, poor inhaler technique, and high device cost. Most respondents considered spacers more effective than nebulizers, and cylindrical spacers were the preferred design.

Conclusions: The findings demonstrate widespread acceptance of spacer devices in respiratory care, particularly in asthma and COPD management. However, gaps in patient education, inhaler technique, and accessibility remain important barriers, highlighting the need for improved awareness initiatives and user-friendly spacer designs to optimize treatment outcomes.

References

Viegi G, Maio S, Fasola S, Baldacci S. Global Burden of Chronic Respiratory Diseases. J Aerosol Med Pulm Drug Deliv. 2020;33(4):171-7.

Sutherland ER, Martin RJ. Airway inflammation in chronic obstructive pulmonary disease: comparisons with asthma. J Allergy Clin Immunol. 2003;112(5):819-27.

Usmani OS, Lavorini F, Marshall J, Dunlop WC, Heron L, Farrington E, Dekhuijzen R. Critical inhaler errors in asthma and COPD: a systematic review of impact on health outcomes. Respiratory Res. 2018;19(1):10.

Vincken W, Levy ML, Scullion J, Usmani OS, Dekhuijzen PR, Corrigan CJ. Spacer devices for inhaled therapy: why use them, and how? ERJ Open Res. 2018;4(2):00065-2018.

Hagmeyer L, van Koningsbruggen‐Rietschel S, Matthes S, Rietschel E, Randerath W. From the infant to the geriatric patient-Strategies for inhalation therapy in asthma and chronic obstructive pulmonary disease. Clin Respiratory J. 2023;17(6):487-98.

Nair A, Menzies D, Hopkinson P, McFarlane L, Lipworth BJ. In vivo comparison of the relative systemic bioavailability of fluticasone propionate from three anti‐static spacers and a metered dose inhaler. Brit J Clin Pharmacol. 2009;67(2):191-8.

Lavorini F, Fontana GA. Targeting drugs to the airways: the role of spacer devices. Expert Opinion Drug Delivery. 2009;6(1):91-102.

Kaplan A, Price D. Matching inhaler devices with patients: the role of the primary care physician. Canad Respiratory J. 2018;2018(1):9473051.

Jindal SK, Gupta D, Aggarwal AN, Agarwal R. Guidelines for management of asthma at primary and secondary levels of health care in India (2005). Indian J Chest Dis Allied Sci. 2005;47(4):309-43.

Indian Medical Association. Recommendations on management of asthma in primary care. New Delhi: Indian Medical Association; 2020. Available at: https://ima-india.org/ima/pdfdata/Recommendations-for-management-of-asthma-in-primary-care-22-12-2020.pdf. Accessed on 22 March 2026.

Dekhuijzen PN, Lavorini F, Usmani OS. Patients’ perspectives and preferences in the choice of inhalers: the case for Respimat® or HandiHaler®. Patient Preference Adherence. 2016;1561-72.

McIvor RA, Devlin HM, Kaplan A. Optimizing the delivery of inhaled medication for respiratory patients: the role of valved holding chambers. Canad Respiratory J. 2018;2018(1):5076259.

Global Initiative for Asthma. Global strategy for asthma management and prevention. 2024. Available at: https://ginasthma.org/wp-content/uploads/2024/ 05/GINA-2024-Strategy-Report-24_05_22_ WMS.pdf. Accessed on 14 March 2026.

Hess DR, Anderson P, Dhand R, Rau JL, Smaldone GC, Guyatt G. Device selection and outcomes of aerosol therapy: Evidence-based guidelines. Chest. 2005;127(335):335-71.

Cates CJ, Crilly JA, Rowe BH. Holding chambers (spacers) versus nebulisers for beta‐agonist treatment of acute asthma. Cochrane Database System Rev. 2006(2):CD000052.

Amirav I, Newhouse MT. Metered-dose inhaler accessory devices in acute asthma: efficacy and comparison with nebulizers: a literature review. Arch Pediat Adolescent Med. 1997;151(9):876-82.

Melani AS, Bonavia M, Cilenti V, Cinti C, Lodi M, Martucci P, et al. Inhaler mishandling remains common in real life and is associated with reduced disease control. Respiratory Med. 2011;105(6):930-8.

Rau JL. Practical problems with aerosol therapy in COPD. Respiratory care. 2006;51(2):158-72.

Giraud V, Roche N. Misuse of corticosteroid metered-dose inhaler is associated with decreased asthma stability. Euro Resp J. 2002;19(2):246-51.

Molimard M, Raherison C, Lignot S, Depont F, Abouelfath A, Moore N. Assessment of handling of inhaler devices in real life: an observational study in 3811 patients in primary care. J Aerosol Med. 2003;16(3):249-54.

Chrystyn H, van der Palen J, Sharma R, Barnes N, Delafont B, Mahajan A, et al. Device errors in asthma and COPD: systematic literature review and meta-analysis. NPJ Primary Care Respiratory Med. 2017;27(1):22.

Sanchis J, Gich I, Pedersen S, Team AD. Systematic review of errors in inhaler use: has patient technique improved over time. Chest. 2016;150(2):394-406.

Price DB, Román-Rodríguez M, McQueen RB, Bosnic-Anticevich S, Carter V, Gruffydd-Jones K, et al. Inhaler errors in the CRITIKAL study: type, frequency, and association with asthma outcomes. J Allergy Clin Immunol. 2017;5(4):1071-81.

Arora P, Kumar L, Vohra V, Sarin R, Jaiswal A, Puri MM, et al. Evaluating the technique of using inhalation device in COPD and bronchial asthma patients. Respir Med. 2014;108(7):992-8.

Dahiya B, Mathew JL, Singh M. Randomized trial of spacers in asthma. Indian J Pediatr. 2007;74(7):631-5.

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Published

2026-07-04

How to Cite

Jain, P., Gondane, A., Pawar, D., & Sharma, A. (2026). Physician perspectives on spacer device usage, prescription patterns, and clinical decision-making factors in the management of respiratory conditions: a nationwide, multicenter cross-sectional observational study. International Journal of Advances in Medicine. https://doi.org/10.18203/2349-3933.ijam20262324

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Original Research Articles