Hematological profile and pregnancy: a review

Simran Kaur, Sabina Khan, Aruna Nigam

Abstract


Many physiological hematological changes occur during pregnancy to accommodate the demands of the developing foetus. Infect, these changes may appear to be pathological in the non-pregnant state. Although physiological in nature, but abnormal hematological profile does affect pregnancy and its outcome. One of the most important underlying cause of maternal mortality is due to underlying hematological complications. This review deals with thorough understanding of range of these haematological parameters during pregnancy.


Keywords


Hematological parameters, Physiology, Pregnancy

Full Text:

PDF

References


Datta D, Datta P. Maternal mortality in india: problems and strategies. Asian J Med Res. 2013;2(1):31-5.

Chandra S, Tripathi A, Mishra S, Amzarul M. Physiological changes in hematological parameters during pregnancy. Indian J Hematol Blood Transfus. 2012;28(3):144-6

Dennen F, Ocaña J, Karasik S, Egan L, Paredes N, Flisser A, et al. Comparison of hemodynamic, biochemical and hematological parameters of healthy pregnant women in the third trimester of pregnancy and the active labor phase. BMC Pregnancy Childbirth. 2011;11:33.

Salas SP, Rosso P, Espinoza R, Robert JA, Valdes G, Donoso E. Maternal plasma volume expansion and hormonal changes in women with idiopathic fetal growth retardation. Obstet Gynecol. 1993;81:1029-33.

Akinbami AA, Ajibola SO, Rabiu KA, Adewunmi AA, Dosunmu AO, Adediran A, et al. Hematological profile of normal pregnant women in Lagos, Nigeria. Int J Women’s Health. 2013;5(1):227-32

Lind T. Hematologic system. Maternal physiology. Washington: CREOG. 1985;25:7-40.

Bernstein IM, Ziegler W, Badger GJ. Plasma volume expansion in early pregnancy. J Obstet Gynecol. 2001;97:669

DeMayer EM, Tegman A. Prevalence of anaemia in the world. WHO Qlty. 1998;38:302-16.

Whittaker PG, Macphail S, Lind T. Serial haematological changes and pregnancy outcome. Obstet Gynecol. 1996;88(1):33-9.

James TR, Reid HL, Mullings MA. Are published standards for hemtological indices in pregnancy applicable across populations: an evaluation in healthy pregnant Jamacian women. BMC Pregnancy Childbirth. 2008;8:8.

Sharma P, Nagar R. Hematological profile of anemic pregnant women attending antenatal hospital. IOSR J Nurs Health Sci. 2013;1(4):11-5.

Mwinga K, Vermund S, ChenY, Mwatha A, Read J, Urassa W, et al. Selected hematologic and biochemical measurements in African HIV-infected and uninfected pregnant women and their infants: the HIV prevention trials network 024 protocol. BMC Pediatrics. 2009;9:49.

Papadopol V, Damian O, Palimaru I, Adam C, Florescu N, Damaceanu D. Maternal hematological and biochemical parameters and pregnancy outcome. J Prev Med. 2001;9(3):27-33.

Ramakers C, van der Woude DA, Verzijl JM, Pijnenborg JM, van Wijk EM. An added value for the hemoglobin content in reticulocytes (CHr) and the mean corpuscular volume (MCV) in the diagnosis of iron deficiency in postpartum anemic women. Int J Lab Hematol. 2012 Oct;34(5):510-6.

Lurie S, Rahamim E, Piper R, Golan A, Sadan O. Total and differential leukocyte counts percentiles in normal pregnancy. Eur J Obstet Gynecol Reprod Biol. 2008;136(1):16-9.

Wadsworth GR. Blood-volume: a commentary. Singapore Med J. 2002;43(8):426-31.

Ramsay M. Changes in WBC count. In: Sue Pavord, Beverley Hunt, eds. Obstetric Hematology Manual. London: Guy’s and St. Thomas’ NHS Foundation Trust and King’s College; 2010: 92-98.

Osonuga IO, Osonuga OA, Onadeko AA, Osonuga A, Osonuga AA. Hematological profile of pregnant women in southwest of Nigeria. Asian Pac J Trop Dis. 2011;1:232-4.

Delgado I, Neubert R, Dudenhausen W. Changes in white blood cells during parturition in mothers and newborn. Gynecol Obstet Invest. 1994;38:227-35

Tzur T, Weintraub AY, Sergienko R, Sheiner E. Can leukocyte count during the first trimester of pregnancy predict later gestational complications? Arch Gynecol Obstet. 2013 Mar;287(3):421-7.

Konijnenberg A, Stokkers E, Vander Post J, Schaap M, Boer K, Bleker O, et al. Extensive platelet activation in preeclampsia compared with normal pregnancy: enhanced expression of cell adhesion molecules. Am J Obstet Gynecol. 1997;176(2):461-9.

Gatti L, Tinconi PM, Guarneri D, Bertuijessi C, Ossola MW, Bosco P, et al. Hemostatic parameters and platelet activation by flow-cytometry in normal pregnancy: a longitudinal study. Internat J Clin Lab Res. 1994;24(4):217-9

Pitkin RM, Witte DL. Platelet and leukocyte counts in pregnancy. JAMA. 1979;242(24):2696-8.

Verma A, Chaudhary H. Study of hematological parameters in advanced pregnancy. Int J Recent Trends Sci Technol. 2013;7(1):16-9.

Onwukeme KE. Puerperal haematological indices in the Nigerian. Afr J Med Med Sci. 1992;21(2):51-5.

Fay RA, Hughes AO, Farron NT. Platelets in pregnancy: hyperdestruction in pregnancy. Obstet Gynecol. 1983;61:238-40.

Ahmed Y, van Iddekinge B, Paul C, Sullivan MHF, Elder MG. Retrospective analysis of platelet numbers and volumes in normal pregnancy and pre-eclampsia. Br J Obstet Gynecol. 1993;100:216-20.

Shehlata N, Burrows RF, Kelton JG. Gestational thrombocytopenia. Clin Obstet Gynecol. 1999;42:327-34

Khellaf M, Loustau V, Bierling P, Michel M, Godeau B. Thrombocytopenia and pregnancy. Rev Med Intern. 2012 Aug;33(8):446-52.