Hydroa vacciniforme: a very rare photodermatosis

K. S. Dhillon, Tarunveer Singh, Deepak Sharma, K. R. Varshney, Nikha Garg, Priyanka Priya, Uroos Fatima, Simmi Chawla

Abstract


Hydroa Vacciniforme (HV) is a rare, acquired and chronic paediatric disorder that is characterized by photosensitivity and recurrent crops of skin lesions on sun-exposed skin, such as the face, ears and hands that heal with vacciniforme scarring. The pathogenesis of HV is unknown. No chromosome abnormality has been identified so far. HV patients have no abnormal laboratory results. The histopathologic features are distinctive and demonstrate intraepidermal multilocular vesicles and cellular necrosis. Most cases remit spontaneously by late adolescence.


Keywords


Hydroa vacciniforme, Photodermatosis

Full Text:

PDF

References


Almeida HL Jr, Kopp J, Jorge VM, Sartori DS, Velloso CD. Extensive hydroa vacciniforme. An Bras Dermatol. 2013 Aug;88(4):620-2.

Yesudian PD, Sharpe GR. Hydroa vacciniforme with oral mucosal involvement. Pediatr Dermatol. 2004;21:555-7.

Gupta G, Mohamed M, Kemmett D. Familial hydroa vacciniforme. Br J Dermatol. 1999;140:124-6.

Wisuthsarewong W, Leenutaphong V, Viravan S. Hydroa vacciniforme with ocular involvement. J Med Assoc Thai. 1998 Oct;81(10):807-11.

Hawk JLM, Ferguson J, Hönigsmann H. Hydroa vacciniforme. In: Wolff K, Goldsmith LA, Katz SI, Gilchrest BA, Paller AS, Leffell DJ, eds. Fitzpatrick's Dermatology in General Medicine. 7th ed. New York: McGraw-Hill; 2008: 820.

Eramo LR, Garden JM, Esterly NB. Hydroa vacciniforme. Diagnosis by repetitive ultraviolet-A phototesting. Arch Dermatol. 1986;122:1310-3.

Halasz CL, Leach EE, Walther RR, Poh-Fitzpatrick MB. Hydroa vacciniforme: induction of lesions with ultraviolet A. J Am Acad Dermatol. 1983 Feb;8(2):171-6.

Cho KH, Li KS, Kim YK, Jeon YK, Kim CW, Lee SK, et al. Epstein-Barr virus associated lymphoproliferative lesion presenting as a hydroa vacciniforme-like eruption. Korean J Dermatol. 2004;42:846-55.

Sonnex TS, Hawk JL. Hydroa vacciniforme: a review of ten cases. Br J Dermatol. 1988;118:101-8.

Choi JH, Hann SK, Yoon MS, Choi BM, Ahn SK, Park YK. Hydroa vacciniforme: recurrence at adulthood and confirmative diagnosis by repetitive ultraviolet-A phototesting. Ann Dermatol. 1989;1:83-6.

Epstein JH. Polymorphous light eruption. J Am Acad Dermatol. 1980;3:329-43.

Elpern DJ, Morison WL, Hood AF. Papulovesicular light eruption. A defined subset of polymorphous light eruption. Arch Dermatol. 1985;121:1286-8.

Redeker AG, Bronow RS. Erythropoietic protoporphyria presenting as hydroa aestivale. Arch Dermatol. 1964;89:104-9.

Wheeler CE, Cawley EP, Whitmore CW. Hydroa aestivale in identical twins. Arch Dermatol. 1960;82:590-4.

Goldgeier MH, Nordlund JJ, Lucky AW, Sibrack LA, McCarthy MJ, McGuire J. Hydroa vacciniforme: diagnosis and therapy. Arch Dermatol. 1982;118:588-91.

Annamalai R. Hydroa vacciniforme in three alternate siblings. Arch Dermatol. 1971 Feb;103(2):224-5.

Ziering CL, Rabinowitz LG, Esterly NB. Antimalarials for children: indications, toxicities, and guidelines. J Am Acad Dermatol. 1993 May;28(5 Pt 1):764-70.

Bruderer P, Shahabpour M, Christoffersen S, André J, Ledoux M. Hydroa vacciniforme treated by a combination of beta-carotene and canthaxanthin. Dermatology. 1995;190(4):343-5.

Omenn GS, Goodman GE, Thornquist MD, Balmes J, Cullen MR, Glass A, et al. Effects of a combination of beta carotene and vitamin A on lung cancer and cardiovascular disease. N Engl J Med. 1996 May;334(18):1150-5.

The Alpha-Tocopherol, Beta Carotene Cancer Prevention Study Group. The effect of vitamin E and beta carotene on the incidence of lung cancer and other cancers in male smokers. N Engl J Med. 1994 Apr;330(15):1029-35.

Blackwell V, McGregor JM, Hawk JL. Hydroa vacciniforme presenting in an adult successfully treated with cyclosporin A. Clin Exp Dermatol. 1998 Mar;23(2):73-6.

Rhodes LE, White SI. Dietary fish oil as a photoprotective agent in hydroa vacciniforme. Br J Dermatol. 1998 Jan;138(1):173-8.

Rhodes LE, Durham BH, Fraser WD, Friedmann PS. Dietary fish oil reduces basal and ultraviolet B-generated PGE2 levels in skin and increases the threshold to provocation of polymorphic light eruption. J Invest Dermatol. 1995 Oct;105(4):532-5.

Durbec F, Reguiaï Z, Léonard F, Pluot M, Bernard P. Efficacy of ω-3 polyunsaturated fatty acids for the treatment of refractory hydroa vacciniforme. Pediatr Dermatol. 2012 Jan-Feb;29(1):118-9.