Pregnancy with Wilson’s disease complicated with thrombocytopenia: a case report

Neema Acharya, S. Samal ., Sunilkumar ., Sourya Acharya, Samarth Shukla


Wilson’s disease in pregnancy is rare. It manifests in the form of liver and neurological disorder due to abnormal copper accumulation. Pregnancy becomes high risk due to involvement of liver and high incidence of abortion, preeclampsia, HELLP syndrome. High risk pregnancy management and treatment with zinc sulphate have shown successful pregnancy outcomes. Reporting here a case of pregnancy with Wilson’s complicated with thrombocytopenia managed successfully.


Pregnancy, Wilson’s disease, Thrombocytopenia

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Anthony Fauci, Eugene Braunwald, Dennis Kasper, Stephen Hauser, Dan Longo, J. Jameson, et al. Wilson’s Disease. In: Brewer George J, eds. Harrison’s Principle of Internal Medicine. 17th ed. New York: McGraw-Hill; 2008: 2449-2451.

European Association for the Study of the Liver. EASL clinical practice guidelines: Wilson’s disease. J Hepatol. 2012;56(3):671-85.

Shervin AL, Beck IT, Mckenna RD. The course of Wilson’s disease (hepatolenticular degeneration) during pregnancy and after delivery. Can Med Assoc J. 1960;83(4):160-3.

Ayesha Malik, Ali Khawaja, Lumaan Sheikh. Wilson’s disease in pregnancy: case series and review of literature. BMC Res Notes. 2013;6:421.

Członkowska A, Gromadzka G, Büttner J, Chabik G. Clinical features of haemolysis, elevated liver enzymes, and low platelet count syndrome in undiagnosed Wilson’s disease: report of two cases. Arch Gynaecol Obstet. 2010;281:129-34.

Brewer GJ, Johnson VD, Dick RD, Fink JK, Kluin KJ. Treatment of Wilson’s disease with zinc, XVII: treatment during pregnancy. Hepatology. 2000;31:364-70.