Juan-Ron fever: a rare case report

Authors

  • Sourya Acharya Department of Medicine, JN Medical College, DMIMS University, Sawangi (Meghe), Wardha-442004, M.H., India
  • Samarth Shukla Department of Pathology, JN Medical College, DMIMS University, Sawangi (Meghe), Wardha-442004, M.H., India
  • Nitin Raisinghani Department of Medicine, JN Medical College, DMIMS University, Sawangi (Meghe), Wardha-442004, M.H., India
  • Rasika Thakare Department of Medicine, JN Medical College, DMIMS University, Sawangi (Meghe), Wardha-442004, M.H., India

Keywords:

Rosai Dorfman disease, SHML, Histiocytes, Lymphadenopathy

Abstract

Juan-Ron fever named after Jaun Rosai and Ronald Dorfman is the fever associated with Rosai Dorfman disease also known as Sinus Histiocytosis with Massive Lymphadenopathy (SHML). It is a rare disorder of unknown etiology that is characterized by abundant histiocytes in the lymph nodes throughout the body. Usually patient presents with painless lymphadenopathy. We present a case of a 45 year old male who presented to us with bilateral cervical lymphadenopathy and fever, later on diagnosed to have SHML.

References

Rosai J, Dorfman RF. Sinus histiocytosis with massive lymphadenopathy. Arch Pathol. 1969;87:63-70.

Juskevicius R, Finlay JL. Rosai-Dorfman disease of the parotid gland, cytologic and histopathologic findings with immunohistochemical correlation. Arch Pathol Lab Med. 2001;125:1348-50.

Foucar E, Rosai J, Dorfman R. Sinus histiocytosis with massive lymphadenopathy (Rosai-Dorfman disease): review of the entity. Sem Diagn Pathol. 1990;7:19-73.

Lauwers GY, Perez-Atayde A, Dorfman RF, Rosai J. The digestive system manifestations of Rosai-Dorfman disease (sinus histiocytosis with massive lymphadenopathy): review of 11 cases. Hum Pathol. 2000;31:380-5.

Ambati S, Chamyan G, Restrepo R, Escalon E, Fort J, Pefkarou A, et al. Rosai-Dorfman disease following bone marrow transplantation for pre-B cell acute lymphoblastic leukemia. Pediatr Blood Cancer. 2008;51:433-5.

Lu D, Estalilla OC, Manning JT Jr, Medeiros LJ. Sinus histiocytosis with massive lymphadenopathy and malignant lymphoma involving the same lymph node: a report of four cases and review of the literature. Modern Pathol. 2000;13:414-9.

Tsang WY, Yip TT, Chan JK. The Rosai-Dorfman disease histiocytes are not infected by Epstein-Barr virus. Histopathology. 1994;25:88-90.

McClain LK, Natkunam Y, Swerdlow HS. Atypical cellular disorders. Hematology. 2004;1:283-322.

Foucar E, Rosai J. Dorfman R. Sinus histiocytosis with massive lymphadenopathy (Rosai-Dorfman disease): review of the entity. Semin Diagn Pathol. 1990;7:19-73.

Lauwers GY, Perez-Atayde A, Dorfman RF, Rosai J. The digestive system manifestations of Rosai-Dorfman disease (sinus histiocytosis with massive lymphadenopathy): review of 11 cases. Hum Pathol. 2000;31:380-5.

Antonius JI, Farid SM, Baez-Giangreco A. Steroid-responsive Rosai-Dorfman disease. Pediatr Hematol Oncol. 1996 Nov-Dec;13(6):563-70.

Komp DM. The treatment of sinus histiocytosis with massive lymphadenopathy (Rosai-Dorfman disease). Semin Diagn Pathol. 1990;7:83-6.

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Published

2017-02-11