Multiple extragastrointestinal stromal tumors: a case report
Keywords:
Extragastrointestinal stromal tumour, Omentum, Peritoneum, Mesentery, DOG-1 markerAbstract
Gastro-Intestinal Stromal Tumor (GIST) is a non-epithelial, mesenchymal tumor. They most commonly originate from the stomach or small intestine, but in rare examples they involve the omentum in this article, we are reporting a case of multiple extragastrointestinal stromal tumour of the omentum, peritoneum and mesentery which was diagnosed cytologically and confirmed by histopathology and immunohistochemistry.
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References
Mazur MT, Clark HB. Gastric stromal tumors: Reappraisal of histogenesis. Am J Surg Pathol. 1983;7:507-19.
Hirota S, Isozaki K, Moriyama Y, Hashimoto K, Nishida T, Ishiguro S, et al. Gain-of-function mutations of C-kit in human gastrointestinal stromal tumours. Science. 1998 Jan;:279(5350):577-80.
Reith JD, Goldblum JR, Lyles RH, Weiss SW. Extragatrointestinal stromal tumours: an analysis of 48 cases with emphasis on histologic predictors of outcome. Mod Pathol. 2000;13(5):577-85.
Yamamoto H, Oda Y, Kawaguchi K, Nakamura N, Takahira T, Tamiya S, et al. C-kit and PDGFRA mutations in extragastrointestinal stromal tumour (gastrointestinal stromal tumour of the soft tissue). Am J Surg Pathol. 2004;28(4):479-88.
Miettinen M, Monihan JM, Sarlomo-Rikala M, Kovatich AJ, Carr NJ, Emory TS, et al. Gastrointestinal stromal tumours/smooth muscle tumours (GISTs) primary in the omentum and mesentery: clinico-pathologic and immunohistochemical study of 26 cases. Am J Surg Pathol. 1999;23(9):1109-18.
Lee JR, Anstadt MP, Khwaja S, Green LK. Gastrointestinal stromal tumour of the posterior mediastinum. Eur J Cardiothorac Surg. 2002;22:1014-6.
Hu X, Forster J, Damjanov I. Primary malignant gastrointestinal stromal tumour of the liver. Arch Pathol Lab Med. 2003;127:1606-8.
Yamaura K, Kato K, Miyazawa M, Haba Y, Muramatsu A, Miyata K, et al. Stromal tumour of the pancreas with expression of C-kit protein: report of a case. J Gastroenterol Hepatol. 2004;19:467-70.
Krokowski M, Jocham D, Choi H, Feller AC, Horny HP. Malignant extragastrointestinal stromal tumour of bladder. J Urol. 2003;169(5):1790-1.
Wingen CB, Pauwels PA, Debiec-Rychter M, van Gemert WG, Vos MC. Uterine gastrointestinal stromal tumour (GIST). Gynecol Oncol. 2005;97(3):970-2.
Vanderwinden JM, Rumessen JJ, DeLaet MH, Vanderhaeghen JJ, Schiffmann SN. CD34+ cells in human intestine are fibroblasts adjacent to, but distinct from, interstitial cells of Cajal. Lab Invest. 1999;79:59-65.
Sinha R, Verma R, Kong A. Mesenteric Gastrointestinal Stromal tumour in a patient with neurofibromatosis. AJR. 2004;183:1844-6.
Weiss SW, Goldblum JR. Fibromatoses. In: Enzinger FM, Weiss SW, eds. Soft Tissue Tumours. 5th ed. St. Louis: Mosby; 2008: 247-249.
Gupta N, Mittal S, Lal N, Misra R, Kumar L, Bhalla S. A rare case of primary mesenteric gastrointestinal stromal tumour with metastasis to the cervix uteri. World J Surg Oncol. 2007;5:137.
