Comparison of body mass index and lipid accumulation product as a better indicator of metabolic syndrome


  • Yashavanth H. S. Department of Medicine, Bangalore Medical College and Research Institute, Bengaluru, Karnataka, India
  • Bharath M. S. Department of Medicine, Bangalore Medical College and Research Institute, Bengaluru, Karnataka, India





Background: Metabolic syndrome (MS) is defined to be cluster of metabolic interrelated risk factors of such as obesity, elevated blood pressures, glucose metabolism disturbances and dyslipidemia. "Lipid accumulation product" (LAP) – is a simple and novel index based on a combination of an anthropometric dimension and a metabolic dimension.

Methods: One hundred patients with metabolic syndrome were included in study. Data was collected through a prepared proforma which included various parameters related to history, thorough clinical examination, and laboratory parameters. Further the patients were assessed for the body mass index (BMI) and lipid accumulation product (LAP). BMI and LAP then correlated with metabolic syndrome.

Results: Our present study is conducted among the population meeting the IDF criteria of MS, with a mean age of 54.52±12.65years and female predominance (54%). 72% and 62% of the study group had Diabetes Mellitus and Hypertension respectively. The mean BMI in our study is 29.04±5.11 kg/m2 with 25% of the population are non-obese. The average LAP value in our present study is 111.51±59.71 cm mmol/l and shown increasing trend with increasing age. LAP had a mean value of 85.19 cm mmol/l, 118.52 cm mmol/l and 122.37 cm mmol/l in the study population satisfying 3/5, 4/5 and 5/5 criteria of Metabolic Syndrome respectively. This shows LAP (P<0.001) has better correlation with MS when compared to BMI (P<0.001) in ANOVA test. In our present study, the presence of diabetes mellitus resulted in significant elevated LAP values i.e. 85.10±31.40 cm mmol/l among non-diabetics to 121.78±64.92 cm mmol/l among diabetics, which is of statistical significance (p value 0.005).

Conclusions: LAP showed strong positive correlation with metabolic syndrome and it also positively correlated with increasing number of components of metabolic syndrome. LAP found to be better predictor of MS than BMI.


Cornier MA, Dabelea D, Hernandez TL, Lindstrom RC, Steig AJ, Stob NR et al. The metabolic syndrome. Endocr Rev. 2008;29:777-822.

Kahn HS. The “lipid accumulation product” performs better than the body mass index for recognizing cardiovascular risk:a population-based comparison. BMC Cardiovascular Disorders. 2005;5-26.

Taverna MJ, Marinez-Larrad MT, Frechtel GD, Serrano-Rios M. Lipid accumulation product: a powerful marker of metabolic syndrome in healthy population. European J Endocrinology. 2011;164: 559-67.

Yang C, Guo ZR, Hu XS, Zhou ZY, Wu M. A prospective study on the association between lipid accumulation product or body mass index and diabetes. Zhonghua Liu Xing Bing XueZaZhi. 2010;31:5-8.

Eckel RH. The Metabolic Syndrome.In: Dennis L. Kasper, Dan L Longo, Stephen L. Hauser, Anthony S Fauci, J. Larry Jameson, Joseph Loscalzo,eds. Harrison’s principle of internal medicine.19th ed. New York, NY:Mcgraw-Hill; 2015:2440-54.

Shashank R Joshi.Disorders of Adipose Tissue and Obesity.In:Yash Pal Munjal, A.K. Agarwal, Pritam Gupta, Sandhya A. Kamath, Milind Y. Nadkar, R.K. Singal ,eds. API textbook of Medicine. 9th edition.New Delhi:The Association of physicians of India; 2012:1275-78.

Kahn HS. The lipid accumulation product is better than BMI for identifying diabetes. Diabetes Care. 2006;29:151-3.

National Cholesterol Education Program (NCEP). Third Report of the National Cholesterol Education Program Expert Panel on Detection, Evaluation, and Treatment of High Blood Cholesterol in Adults (Adult Treatment Panel III) final report. Circulation 2002;106:3143-421.

Bruna Angelo Vieira, Patricia Sauer, AlineMarcadenti ,Carla Haas Piovesan. Association between LAP Index (lipid accumulation product) and metabolic profile in hospitalized patients. Nutr Hosp 2015;31(6):2771-4.

Hamsaveena, Shalini M, Cariappa KB. Lipid Accumulation Product as a Novel Index to Predict Diabetes in Women. RES J Pharm Biol Chem SCI 2014;5(2):760-63.

Bozorgmanesh M, Hadaegh F, Azizi F. Diabetes prediction, lipid accumulation product, and adiposity measures; 6-year follow-up: Tehran lipid and glucose study. Lipids Health Dis. 2010;9:45.

XinGao, Guiyan Wang, Aili Wang, Tan Xu, Weijun Tong, Yonghong Zhang. Comparison of lipid accumulation product with body mass index as an indicator of hypertension risk among Mongolians in China. Obesity Research and Clinical Practice. 2013;7:e308-314.






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