Clinico-pathological study of primary carcinoma of the liver


  • P. Dasharatham Department of General Medicine, Malla Reddy Medical College for Women, Suraram, Hyderabad, Telangana, India
  • P. Arun Kumar Department of Nephrology, Osmania Medical College, Koti, Hyderabad, Telangana, India



Cirrhosis, Histopathology, Primary carcinoma of the liver


Background: Since the incidence of the primary carcinoma of the liver in Warangal is very high when compared to other parts of the country, the possible etiological factors have been studied for the increasing frequency of Primary carcinoma of the liver with a view for further follow up. The objective of the present study was to undertake a thorough study of histopathological changes, typing and its association with cirrhosis.

Methods: A hospital based cross sectional study was carried for a period of three years among 56 cases of primary carcinoma of the liver at MGM hospital. Institutional Ethics Committee permission was obtained. Informed consent was taken from each and every patient. Detailed history, clinical examination and investigations were carried out for each and every included patient. Liver biopsy was done under strict aseptic precautions.

Results: The incidence of Primary carcinoma of the liver was found to be highest in males as compared to females. The highest incidence of Primary carcinoma of the liver was found in the age group of 41-50 years. In only 14.3% of cases the Primary carcinoma of the liver was associated with cirrhosis of liver. The most common type of cell found on histopathology was cylindroids type in 35.7% of cases followed by trabecular type in 28.5% of cases.

Conclusions: Incidence of Primary carcinoma of the liver was found to be very high. This was not associated with corresponding increase in cirrhosis. The cause of their increase was obscure.


Alpert ME, Hutt MSR, Davidson CS. Mycotoxins: a possible cause of primary carcinoma of the liver. Am J Med. 1969;46:325-9.

Alpert E. Alpha-fetoproteins: In: Popper H, Schaffner F, editors. Development of biology and clinical significance in liver disease. 8th Ed. New York: Grune and Stration; 1975.

Mourad W, Khalaf H, Tulbah A. Clinicopathologic features of hepatic neoplasms in explanted livers: a single institution experience. Ann Saudi Med. 2007;27(6):437-41.

Caroli-Bottino A, Nascimento CM, Basto S, Ribeiro J, Silveira V, Carvalho AM, Castro PN, Villela-Nogueiro CA, Pannain VL. Hepatocellular carcinoma: incidental finding in cirrhotic explanted livers. In Transplantation proceedings 2005;37(6):2791-2.

Terada T, Tersaki S, Nakanuma Y. A clinicopathologic study of adenomatous hyperplasia of the liver in 209 consecutive cirrhotic livers examined by autopsy. Cancer. 1993;72(5):1551-6.

Kaji K, Terada T, Nakanuma Y. Frequent occurrence of hepatocellular carcinoma in cirrhotic livers after surgical resection of atypical adenomatous hyperplasia (borderline hepatocellular lesion): a follow-up study. Am J Gastroenterol. 1994;89(6):903-8.

Kobayashi M, Okabayashi T, Okamoto K, Namikawa T, Araki K. A clinicopathologic study of primary adenosquamous carcinoma of the liver. J Clin Gastroenterol. 2005;39(6):544-8.

Maeda T, Takenaka K, Tguchi K, Kajiyama K, Shirabe K, Shimada M et al. Adenosquamous carcinoma of the liver: clinicopathologic characteristics and cytokeratin profile. Cancer 1997;80(3):364-71.

Farley JH, Hickey KW, Carlson JW. Adenosquamous histology predicts a poor outcome for patients with advanced-stage, but not early-stage, cervical carcinoma. Cancer. 2003;97(9):2196-202.

Le Bail B, Belleannee G, Bernard PH, Saric J, Balabaud C, Bioulac-Sage P. Adenomatous hyperplasia in cirrhotic livers: histological evaluation, cellular density, and proliferative activity of 35 macronodular lesions in the cirrhotic explants of 10 adult French patients. Human pathology. 1995;26(8):897-906.






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