Published: 2017-03-23

Clinical and biochemical profile of patients with viral hepatitis at tertiary care centre

Sidheshwar Virbhadraappa Birajdar, Sheshrao Sakharam Chavan, Sanjay A. Mundhe, Manisha G. Bhosale


Background: Viral hepatitis is known since ancient times. Hepatitis is an inflammation of the liver, most commonly caused by a viral infection. Different species of viruses, including Cytomegalovirus, Epstein-Barr, Herpes simplex, Adenovirus, Coxsackie virus and others cause parenchymal hepatic inflammation, but the term viral hepatitis generally implies to the five hepatotropic viruses: Hepatitis A, B, C, D and E virus.

Methods: This observational study was done from August 2014 to November 2016 in department of medicine of a medical college using a structured questionnaire.

Results: Anorexia was the most common symptom; followed by fatigue; nausea and vomiting. Total serum bilirubin and direct serum bilirubin were raised in all cases of hepatitis A and E. Raised SGPT and SGOT were observed in all cases of Hepatitis A and E. Among 43 patients of hepatitis B, SGPT and SGOT were raised in 32 and 31 cases respectively. Raised alkaline phosphatase was observed in 27; 25 and 16 cases of hepatitis A; B and E respectively.  Raised prothrombin time was observed in 12; 11; 01and 09 of Hepatitis A; B; C and E cases respectively.

Conclusions: Viral hepatitis is an important heath care problem in India as it occurs epidemically and sporadically. The variability in nature of the disease regarding its onset, presenting symptoms, clinical course and development of complications are important aspects.  So, it is very essential for health care professionals to be aware of all aspects of it so that it is detected and treated early.


Biochemical profile, Clinical profile, Viral hepatitis

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Satsangi S, Dhiman R. Combating the wrath of viral hepatitis in India. Indian J Med Res. 2016;144(1):1.

Kumar M, Sarin SK. Viral hepatitis eradication in India by 2080- gaps, challenges and targets. Indian J Med Res. 2014;140:1-4.

Jain P, Prakash S, Gupta S, Singh KP, Shrivastava S, Singh DD, et al. Prevalence of hepatitis A virus, hepatitis B virus, hepatitis C virus, hepatitis D virus and hepatitis E virus as causes of acute viral hepatitis in North India: a hospital based study. Indian J Med Microbiol. 2013;31(3):261-5.

Dabadghao V, Barure R, Sharma S, Mangudkar S. A study of the clinical and biochemical profile of acute viral hepatitis. Int J Biomed Adv Res. 2015;6(10):689-93.

Acharya SK, Madan K, Dattagupta S, Panda SK. Viral hepatitis in India. Natl Med J India. 2006;19(4):203-17.

Chandra NS, Sharma A, Rai RR, Malhotra B. Contribution of hepatitis E virus in acute sporadic hepatitis in North Western India. Indian J Med Res. 2012;136(3):477-82.

Irshad M, Singh S, Ansari MA, Joshi YK. Viral Hepatitis in India: a report from Delhi. Glob J Health. 2010;2(2):96-103.

Shapiro CN, Margolis HS. Worldwide epidemiology of hepatitis A virus infection. J Hepatol. 1993;18(2):S11-4.

Tandon B, Acharya S, Tandon A. Epidemiology of hepatitis B virus infection in India. Gut. 1996;38(2):S56-9.

Tandon B, Gupta H, Irshad M, Joshi YK, Chawla TC. Associated infection with non-A, non-B virus as possible cause of liver failure in Indian HBV carriers. Lancet. 1984;2(8405):750-1.

Dharmadhikari CA, Kulkarni RD, Kulkarni VA, Udgaonkar US, Pawar SG. Incidence of hepatitis B surface antigen in liver diseases and voluntary blood donors. J Indian Med Assoc. 1990;88(3):73-5.

Karim SSA, Thejpal R, Singh B, Clin D, Virol P. High prevalence of hepatitis B virus infection in rural black adults in Mseleni, South Africa. Am J Public Health. 1989;79(7):893-4.

Ichhpujani RL, Riley IW, Duggal L, Kumari S, Gupta PS, Sehgal S. Demographic features of sporadic acute hepatitis as determined by viral hepatitis markers. J Commun Dis. 1991;23(2):138-43.

Kamat SP, Mehta PR, Paranjpe SM, Ingole NA. Hepatitis B virus (HBV) infection in liver disease patients in mumbai, india with special reference to hepatitis B surface antigen (HBsAg) mutant detection. J Clin diagnostic Res. 2014;8(3):19-21.

Modi TN, Patel SA, Mirani KM, Vaghasiya DR, Makadia GS, Usdadiya J. A study of clinical profile and outcome in acute viral hepatitis E. Indian J Clin Pract. 2013;23(10):635-7.

Chakrabarti K, Ballala K, Rao K, Patil N. A study to assess the clinical and biochemical profile of patients diagnosed with hepatitis E in a large teaching hospital of Southern India. Asian J Pharm Clin Res. 2016;9(2):84-9.

Lakshmi TM, Vaithilingam A, Franklin E, Reddy EP. The prevalence of serological markers of viruses causing acute hepatitis in South Indian population. J Biol Med Res Int. 2011;2(4):925-8.

Zhang S, Wang J, Yuan Q, Ge S, Zhang J, Xia N, et al. Clinical characteristics and risk factors of sporadic hepatitis E in Central China. Virol J. 2011;8:1-5.

Tong MJ, El-Farra NS, Grew MI. Clinical manifestations of hepatitis A: recent experience in a community teaching hospital. J Infect Dis. 1995;171:S15-8.

Ashraf-Uz-Zaman M, Begum B, Asad H. Biochemical parameters in common viral hepatitis. J Med. 2010;11:42-5.

Anand BS, Velez M. Assessment of correlation between serum titers of hepatitis C virus and severity of liver disease. World J Gastroenterol. 2004;10(16):2409-11.

Kivel RM. Hematologic aspects of acute viral hepatitis. Am J Dig Dis. 1961;6(11):1017-31.

Rahman M, Jahan F, Rahman F. Biochemical and immunological parameters of Hepatitis B Virus positive patients in Bangladesh. J Bangladesh Acad Sci. 2013;37(1):51-6.